Specifically, in this experiment set, known experiment labels are:
This report contains all the functional information that was requested by the options when functional_Hunter.R was executed. The functional categories can be:
All the functional categories are computed with ClusterProfiler and GO categories are computed also with TopGo.
Some sections will not show if there are not sinficative results. Each category is analysed using Over representation analysis (ORA) and Gene Set Analysis (GSEA). The ORA method takes a group of significative DEGs (only DEGs, upregulated DEGs or downregulated DEGs) and performs a hypergeometric test for each term of the selected functional category. In the case of the GSEA method, all the genes are sorted by their fold-change and the algorithm scan which genes with similar fold-change shares a term of the selected functional category.
Statistics about input results obtained from DEGenes Expression Hunter are:
| Gene_tag | Genes |
|---|---|
| NOT_DEG | 15848 |
| POSSIBLE_DEG | 255 |
| PREVALENT_DEG | 202 |
Table of signifcant genes. Variables taken into account are being shown into table (except gene symbols/ID). Top of positive (30 items) and negative (26 items) are being shown in two different tables
| rownames | input_IDs | logFC_DESeq2 | logFC_edgeR | mean_logFCs | SYMBOL |
|---|---|---|---|---|---|
| ENSG00000188921 | ENSG00000188921 | 1.74197312456206 | 1.74228392512514 | 1.7421285248436 | HACD4 |
| ENSG00000258752 | ENSG00000258752 | 1.75809108202292 | 1.75616819511886 | 1.75712963857089 | NA |
| ENSG00000279530 | ENSG00000279530 | 1.76290268387243 | 1.75301036860623 | 1.75795652623933 | NA |
| ENSG00000258441 | ENSG00000258441 | 1.7760825636795 | 1.77996997724824 | 1.77802627046387 | LINC00641 |
| ENSG00000249717 | ENSG00000249717 | 1.78531787918718 | 1.7858588990575 | 1.78558838912234 | PARM1-AS1 |
| ENSG00000111371 | ENSG00000111371 | 1.843689679795 | 1.83302778435901 | 1.83835873207701 | SLC38A1 |
| ENSG00000279166 | ENSG00000279166 | 1.85115668380546 | 1.85517266528287 | 1.85316467454417 | NA |
| ENSG00000213891 | ENSG00000213891 | 1.87928368515626 | 1.87572539214103 | 1.87750453864865 | RPL3P6 |
| ENSG00000225313 | ENSG00000225313 | 1.88902917007879 | 1.89286480631346 | 1.89094698819613 | NA |
| ENSG00000134077 | ENSG00000134077 | 1.89185588806699 | 1.89057064601236 | 1.89121326703968 | THUMPD3 |
| ENSG00000213625 | ENSG00000213625 | 1.91082472104738 | 1.90810618133475 | 1.90946545119106 | LEPROT |
| ENSG00000121454 | ENSG00000121454 | 1.93380650924297 | 1.92831627738784 | 1.9310613933154 | LHX4 |
| ENSG00000225572 | ENSG00000225572 | 2.06270994699042 | 2.05286311571601 | 2.05778653135322 | DOCK4-AS1 |
| ENSG00000073584 | ENSG00000073584 | 2.25208183830399 | 2.23878012131638 | 2.24543097981018 | SMARCE1 |
| ENSG00000271533 | ENSG00000271533 | 2.48977340153388 | 2.47565193004794 | 2.48271266579091 | NA |
| ENSG00000235880 | ENSG00000235880 | 4.28569421781593 | 3.99087231306659 | 4.13828326544126 | NA |
| ENSG00000251586 | ENSG00000251586 | 4.2855472216083 | 3.99680892781831 | 4.1411780747133 | NA |
| ENSG00000232344 | ENSG00000232344 | 4.35640415659817 | 4.0726854972581 | 4.21454482692813 | LOC100419436 |
| ENSG00000239503 | ENSG00000239503 | 4.45300601599872 | 4.16126426346173 | 4.30713513973022 | NA |
| ENSG00000279862 | ENSG00000279862 | 4.15219467913303 | 4.88198035756045 | 4.51708751834674 | NA |
| ENSG00000236434 | ENSG00000236434 | 4.22897039377978 | 4.96204105093882 | 4.5955057223593 | NA |
| ENSG00000228166 | ENSG00000228166 | 4.4130961908377 | 5.13609335610494 | 4.77459477347132 | MTND1P11 |
| ENSG00000208028 | ENSG00000208028 | 4.43080090566233 | 5.14219914778293 | 4.78650002672263 | MIR616 |
| ENSG00000274093 | ENSG00000274093 | 4.46751039995011 | 5.19686640469241 | 4.83218840232126 | NA |
| ENSG00000259950 | ENSG00000259950 | 4.47434940757891 | 5.20193033004558 | 4.83813986881225 | NA |
| ENSG00000257475 | ENSG00000257475 | 4.49058063961706 | 5.21053708997933 | 4.8505588647982 | NA |
| ENSG00000265625 | ENSG00000265625 | 4.51258922011669 | 5.22035659802475 | 4.86647290907072 | NA |
| ENSG00000253539 | ENSG00000253539 | 4.66024587128113 | 5.38117831898838 | 5.02071209513475 | NA |
| ENSG00000179038 | ENSG00000179038 | 5.09426473364569 | 5.80355437865827 | 5.44890955615198 | NA |
| ENSG00000085265 | ENSG00000085265 | 5.41025559710872 | 6.11905544475849 | 5.76465552093361 | FCN1 |
| rownames | input_IDs | logFC_DESeq2 | logFC_edgeR | mean_logFCs | SYMBOL |
|---|---|---|---|---|---|
| ENSG00000188921 | ENSG00000188921 | 1.74197312456206 | 1.74228392512514 | 1.7421285248436 | HACD4 |
| ENSG00000258752 | ENSG00000258752 | 1.75809108202292 | 1.75616819511886 | 1.75712963857089 | NA |
| ENSG00000279530 | ENSG00000279530 | 1.76290268387243 | 1.75301036860623 | 1.75795652623933 | NA |
| ENSG00000258441 | ENSG00000258441 | 1.7760825636795 | 1.77996997724824 | 1.77802627046387 | LINC00641 |
| ENSG00000249717 | ENSG00000249717 | 1.78531787918718 | 1.7858588990575 | 1.78558838912234 | PARM1-AS1 |
| ENSG00000111371 | ENSG00000111371 | 1.843689679795 | 1.83302778435901 | 1.83835873207701 | SLC38A1 |
| ENSG00000279166 | ENSG00000279166 | 1.85115668380546 | 1.85517266528287 | 1.85316467454417 | NA |
| ENSG00000213891 | ENSG00000213891 | 1.87928368515626 | 1.87572539214103 | 1.87750453864865 | RPL3P6 |
| ENSG00000225313 | ENSG00000225313 | 1.88902917007879 | 1.89286480631346 | 1.89094698819613 | NA |
| ENSG00000134077 | ENSG00000134077 | 1.89185588806699 | 1.89057064601236 | 1.89121326703968 | THUMPD3 |
| ENSG00000213625 | ENSG00000213625 | 1.91082472104738 | 1.90810618133475 | 1.90946545119106 | LEPROT |
| ENSG00000121454 | ENSG00000121454 | 1.93380650924297 | 1.92831627738784 | 1.9310613933154 | LHX4 |
| ENSG00000225572 | ENSG00000225572 | 2.06270994699042 | 2.05286311571601 | 2.05778653135322 | DOCK4-AS1 |
| ENSG00000073584 | ENSG00000073584 | 2.25208183830399 | 2.23878012131638 | 2.24543097981018 | SMARCE1 |
| ENSG00000271533 | ENSG00000271533 | 2.48977340153388 | 2.47565193004794 | 2.48271266579091 | NA |
| ENSG00000235880 | ENSG00000235880 | 4.28569421781593 | 3.99087231306659 | 4.13828326544126 | NA |
| ENSG00000251586 | ENSG00000251586 | 4.2855472216083 | 3.99680892781831 | 4.1411780747133 | NA |
| ENSG00000232344 | ENSG00000232344 | 4.35640415659817 | 4.0726854972581 | 4.21454482692813 | LOC100419436 |
| ENSG00000239503 | ENSG00000239503 | 4.45300601599872 | 4.16126426346173 | 4.30713513973022 | NA |
| ENSG00000279862 | ENSG00000279862 | 4.15219467913303 | 4.88198035756045 | 4.51708751834674 | NA |
| ENSG00000236434 | ENSG00000236434 | 4.22897039377978 | 4.96204105093882 | 4.5955057223593 | NA |
| ENSG00000228166 | ENSG00000228166 | 4.4130961908377 | 5.13609335610494 | 4.77459477347132 | MTND1P11 |
| ENSG00000208028 | ENSG00000208028 | 4.43080090566233 | 5.14219914778293 | 4.78650002672263 | MIR616 |
| ENSG00000274093 | ENSG00000274093 | 4.46751039995011 | 5.19686640469241 | 4.83218840232126 | NA |
| ENSG00000259950 | ENSG00000259950 | 4.47434940757891 | 5.20193033004558 | 4.83813986881225 | NA |
| ENSG00000257475 | ENSG00000257475 | 4.49058063961706 | 5.21053708997933 | 4.8505588647982 | NA |
| ENSG00000265625 | ENSG00000265625 | 4.51258922011669 | 5.22035659802475 | 4.86647290907072 | NA |
| ENSG00000253539 | ENSG00000253539 | 4.66024587128113 | 5.38117831898838 | 5.02071209513475 | NA |
| ENSG00000179038 | ENSG00000179038 | 5.09426473364569 | 5.80355437865827 | 5.44890955615198 | NA |
| ENSG00000085265 | ENSG00000085265 | 5.41025559710872 | 6.11905544475849 | 5.76465552093361 | FCN1 |
The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.
BarplotThe most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.
The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.
Distributions of Log2FC
This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.
Gene-Concept Network
The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.
The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.
Significant genes (x-axis) and the functional categories in which they appear.
Upsetplot
Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).
The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.
BarplotThe most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.
The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.
Distributions of Log2FC
This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.
Gene-Concept Network
The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.
The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.
Significant genes (x-axis) and the functional categories in which they appear.
Upsetplot
Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).
The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.
BarplotThe most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.
The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.
Distributions of Log2FC
This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.
Gene-Concept Network
The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.
The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.
Significant genes (x-axis) and the functional categories in which they appear.
Upsetplot
Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).
The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.
BarplotThe most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.
The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.
Distributions of Log2FC
This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.
Gene-Concept Network
The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.
The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.
Significant genes (x-axis) and the functional categories in which they appear.
Upsetplot
Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).
The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.
BarplotThe most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.
The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.
Distributions of Log2FC
This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.
Gene-Concept Network
The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.
The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.
Significant genes (x-axis) and the functional categories in which they appear.
Upsetplot
Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0002181 | cytoplasmic translation | 1.31e-19 | NA | NA | 9.11e-03 |
| GO:0006412 | translation | 7.01e-10 | NA | NA | 4.71e-02 |
| GO:0045333 | cellular respiration | 2.79e-07 | NA | NA | NA |
| GO:0032543 | mitochondrial translation | 9.03e-07 | NA | NA | NA |
| GO:0097250 | mitochondrial respirasome assembly | 2.06e-06 | NA | NA | NA |
| GO:0140053 | mitochondrial gene expression | 7.70e-06 | NA | NA | NA |
| GO:0006119 | oxidative phosphorylation | 7.70e-06 | NA | NA | NA |
| GO:0033108 | mitochondrial respiratory chain complex ... | 7.70e-06 | NA | NA | NA |
| GO:0009060 | aerobic respiration | 1.77e-05 | NA | NA | NA |
| GO:0017004 | cytochrome complex assembly | 2.00e-05 | NA | NA | NA |
| GO:0022904 | respiratory electron transport chain | 5.87e-04 | NA | NA | NA |
| GO:0007005 | mitochondrion organization | 1.10e-03 | NA | NA | NA |
| GO:0046165 | alcohol biosynthetic process | 1.26e-03 | NA | NA | NA |
| GO:0015980 | energy derivation by oxidation of organi... | 1.26e-03 | NA | NA | NA |
| GO:0097237 | cellular response to toxic substance | 1.26e-03 | NA | NA | NA |
| GO:0022900 | electron transport chain | 1.26e-03 | NA | NA | NA |
| GO:0042773 | ATP synthesis coupled electron transport | 1.70e-03 | NA | NA | NA |
| GO:0042775 | mitochondrial ATP synthesis coupled elec... | 1.70e-03 | NA | NA | NA |
| GO:0019646 | aerobic electron transport chain | 2.20e-03 | NA | NA | NA |
| GO:0033617 | mitochondrial cytochrome c oxidase assem... | 2.30e-03 | NA | NA | NA |
| GO:1990748 | cellular detoxification | 2.70e-03 | NA | NA | NA |
| GO:0098754 | detoxification | 3.09e-03 | NA | NA | NA |
| GO:0006754 | ATP biosynthetic process | 3.93e-03 | NA | NA | NA |
| GO:0019538 | protein metabolic process | 6.67e-03 | NA | NA | NA |
| GO:0008535 | respiratory chain complex IV assembly | 7.45e-03 | NA | NA | NA |
| GO:0009145 | purine nucleoside triphosphate biosynthe... | 7.49e-03 | NA | NA | NA |
| GO:0061077 | chaperone-mediated protein folding | 7.49e-03 | NA | NA | NA |
| GO:0015986 | proton motive force-driven ATP synthesis | 7.49e-03 | NA | NA | NA |
| GO:0009206 | purine ribonucleoside triphosphate biosy... | 7.49e-03 | NA | NA | NA |
| GO:0098869 | cellular oxidant detoxification | 8.08e-03 | NA | NA | NA |
| GO:1902600 | proton transmembrane transport | 8.08e-03 | NA | NA | NA |
| GO:1901137 | carbohydrate derivative biosynthetic pro... | 8.08e-03 | NA | NA | 2.69e-02 |
| GO:0006121 | mitochondrial electron transport, succin... | 8.08e-03 | NA | NA | NA |
| GO:1901617 | organic hydroxy compound biosynthetic pr... | 8.09e-03 | NA | NA | NA |
| GO:0030003 | intracellular monoatomic cation homeosta... | 8.34e-03 | NA | NA | NA |
| GO:1902253 | regulation of intrinsic apoptotic signal... | 8.34e-03 | NA | NA | NA |
| GO:1901135 | carbohydrate derivative metabolic proces... | 1.01e-02 | NA | NA | NA |
| GO:0045116 | protein neddylation | 1.09e-02 | NA | NA | NA |
| GO:0006091 | generation of precursor metabolites and ... | 1.16e-02 | NA | NA | NA |
| GO:0055086 | nucleobase-containing small molecule met... | 1.51e-02 | NA | NA | 4.18e-02 |
| GO:0006839 | mitochondrial transport | 1.68e-02 | NA | NA | NA |
| GO:0006873 | intracellular monoatomic ion homeostasis | 1.74e-02 | NA | NA | NA |
| GO:0006626 | protein targeting to mitochondrion | 1.74e-02 | NA | NA | NA |
| GO:0031666 | positive regulation of lipopolysaccharid... | 1.78e-02 | NA | NA | NA |
| GO:0006695 | cholesterol biosynthetic process | 1.86e-02 | NA | NA | NA |
| GO:1902653 | secondary alcohol biosynthetic process | 1.86e-02 | NA | NA | NA |
| GO:0051246 | regulation of protein metabolic process | 2.08e-02 | NA | NA | NA |
| GO:0009636 | response to toxic substance | 2.08e-02 | NA | NA | NA |
| GO:0046085 | adenosine metabolic process | 2.62e-02 | NA | NA | NA |
| GO:0070585 | protein localization to mitochondrion | 2.75e-02 | NA | NA | NA |
| GO:0090481 | pyrimidine nucleotide-sugar transmembran... | 3.13e-02 | NA | NA | NA |
| GO:0009954 | proximal/distal pattern formation | 3.15e-02 | NA | NA | NA |
| GO:1900118 | negative regulation of execution phase o... | 3.23e-02 | NA | NA | NA |
| GO:0016126 | sterol biosynthetic process | 3.26e-02 | NA | NA | NA |
| GO:0009201 | ribonucleoside triphosphate biosynthetic... | 3.36e-02 | NA | NA | NA |
| GO:0006457 | protein folding | 3.36e-02 | NA | NA | NA |
| GO:0090151 | establishment of protein localization to... | 3.36e-02 | NA | NA | NA |
| GO:0042776 | proton motive force-driven mitochondrial... | 3.36e-02 | NA | NA | NA |
| GO:0009117 | nucleotide metabolic process | 3.36e-02 | NA | NA | NA |
| GO:0009142 | nucleoside triphosphate biosynthetic pro... | 3.36e-02 | NA | NA | NA |
| GO:0006753 | nucleoside phosphate metabolic process | 3.61e-02 | NA | NA | 4.18e-02 |
| GO:0006694 | steroid biosynthetic process | 3.61e-02 | NA | NA | NA |
| GO:1901857 | positive regulation of cellular respirat... | 3.94e-02 | NA | NA | NA |
| GO:0030162 | regulation of proteolysis | 4.30e-02 | NA | NA | NA |
| GO:0006959 | humoral immune response | 4.35e-02 | NA | NA | NA |
| GO:0006163 | purine nucleotide metabolic process | 4.69e-02 | NA | NA | NA |
| GO:0072521 | purine-containing compound metabolic pro... | 4.69e-02 | NA | NA | NA |
| GO:0030150 | protein import into mitochondrial matrix | 4.78e-02 | NA | NA | NA |
| GO:0006325 | chromatin organization | NA | 3.48e-17 | NA | NA |
| GO:0006338 | chromatin remodeling | NA | 1.35e-16 | NA | NA |
| GO:0016043 | cellular component organization | NA | 3.19e-10 | 1.73e-03 | NA |
| GO:0071840 | cellular component organization or bioge... | NA | 2.09e-08 | 4.96e-02 | NA |
| GO:0000226 | microtubule cytoskeleton organization | NA | 1.50e-07 | NA | NA |
| GO:0007049 | cell cycle | NA | 2.27e-07 | NA | NA |
| GO:0022402 | cell cycle process | NA | 3.30e-07 | NA | NA |
| GO:0051254 | positive regulation of RNA metabolic pro... | NA | 4.08e-07 | NA | NA |
| GO:0007010 | cytoskeleton organization | NA | 4.08e-07 | NA | NA |
| GO:1902680 | positive regulation of RNA biosynthetic ... | NA | 4.08e-07 | NA | NA |
| GO:0045935 | positive regulation of nucleobase-contai... | NA | 4.08e-07 | NA | NA |
| GO:0010564 | regulation of cell cycle process | NA | 4.16e-07 | NA | NA |
| GO:0045893 | positive regulation of DNA-templated tra... | NA | 4.47e-07 | NA | NA |
| GO:0019219 | regulation of nucleobase-containing comp... | NA | 7.84e-07 | NA | NA |
| GO:2001141 | regulation of RNA biosynthetic process | NA | 8.63e-07 | NA | NA |
| GO:0006355 | regulation of DNA-templated transcriptio... | NA | 1.07e-06 | NA | NA |
| GO:0051252 | regulation of RNA metabolic process | NA | 1.27e-06 | NA | NA |
| GO:0051726 | regulation of cell cycle | NA | 2.00e-06 | NA | NA |
| GO:0006366 | transcription by RNA polymerase II | NA | 3.12e-06 | NA | NA |
| GO:0006351 | DNA-templated transcription | NA | 4.02e-06 | NA | NA |
| GO:0007017 | microtubule-based process | NA | 5.15e-06 | NA | NA |
| GO:0090304 | nucleic acid metabolic process | NA | 5.15e-06 | NA | NA |
| GO:0000278 | mitotic cell cycle | NA | 5.98e-06 | NA | NA |
| GO:0051056 | regulation of small GTPase mediated sign... | NA | 6.22e-06 | NA | NA |
| GO:0006357 | regulation of transcription by RNA polym... | NA | 6.22e-06 | NA | NA |
| GO:1903047 | mitotic cell cycle process | NA | 6.22e-06 | NA | NA |
| GO:0050794 | regulation of cellular process | NA | 1.38e-05 | 2.33e-02 | NA |
| GO:0016070 | RNA metabolic process | NA | 1.38e-05 | NA | NA |
| GO:1902679 | negative regulation of RNA biosynthetic ... | NA | 3.94e-05 | NA | NA |
| GO:0045892 | negative regulation of DNA-templated tra... | NA | 4.60e-05 | NA | NA |
| GO:0050789 | regulation of biological process | NA | 4.69e-05 | 1.54e-02 | NA |
| GO:0051276 | chromosome organization | NA | 4.69e-05 | NA | NA |
| GO:0045934 | negative regulation of nucleobase-contai... | NA | 4.92e-05 | NA | NA |
| GO:0000122 | negative regulation of transcription by ... | NA | 9.04e-05 | NA | NA |
| GO:0032774 | RNA biosynthetic process | NA | 9.20e-05 | NA | NA |
| GO:0045944 | positive regulation of transcription by ... | NA | 1.15e-04 | NA | NA |
| GO:0141187 | nucleic acid biosynthetic process | NA | 1.15e-04 | NA | NA |
| GO:0065007 | biological regulation | NA | 1.86e-04 | 3.35e-03 | NA |
| GO:0046777 | protein autophosphorylation | NA | 3.24e-04 | NA | NA |
| GO:0006974 | DNA damage response | NA | 3.54e-04 | NA | NA |
| GO:0000819 | sister chromatid segregation | NA | 4.55e-04 | NA | NA |
| GO:0030261 | chromosome condensation | NA | 4.58e-04 | NA | NA |
| GO:0051253 | negative regulation of RNA metabolic pro... | NA | 4.87e-04 | NA | NA |
| GO:0140014 | mitotic nuclear division | NA | 7.77e-04 | NA | NA |
| GO:0006281 | DNA repair | NA | 8.58e-04 | NA | NA |
| GO:0098534 | centriole assembly | NA | 1.04e-03 | NA | NA |
| GO:0032886 | regulation of microtubule-based process | NA | 1.05e-03 | NA | NA |
| GO:0051128 | regulation of cellular component organiz... | NA | 1.05e-03 | 2.01e-02 | NA |
| GO:0048856 | anatomical structure development | NA | 1.14e-03 | NA | NA |
| GO:0071716 | leukotriene transport | NA | 1.21e-03 | NA | NA |
| GO:0010468 | regulation of gene expression | NA | 1.40e-03 | NA | NA |
| GO:0031023 | microtubule organizing center organizati... | NA | 1.59e-03 | NA | NA |
| GO:0051301 | cell division | NA | 1.66e-03 | NA | NA |
| GO:0007098 | centrosome cycle | NA | 1.70e-03 | NA | NA |
| GO:0007275 | multicellular organism development | NA | 1.80e-03 | NA | NA |
| GO:1905064 | negative regulation of vascular associat... | NA | 1.82e-03 | NA | NA |
| GO:0010556 | regulation of macromolecule biosynthetic... | NA | 1.96e-03 | NA | NA |
| GO:0016310 | phosphorylation | NA | 2.06e-03 | NA | NA |
| GO:0040029 | epigenetic regulation of gene expression | NA | 2.06e-03 | NA | NA |
| GO:0031326 | regulation of cellular biosynthetic proc... | NA | 2.24e-03 | NA | NA |
| GO:0051052 | regulation of DNA metabolic process | NA | 2.31e-03 | NA | NA |
| GO:0007059 | chromosome segregation | NA | 2.92e-03 | NA | NA |
| GO:0000070 | mitotic sister chromatid segregation | NA | 3.39e-03 | NA | NA |
| GO:0022008 | neurogenesis | NA | 3.56e-03 | 4.65e-02 | NA |
| GO:0006139 | nucleobase-containing compound metabolic... | NA | 3.65e-03 | NA | NA |
| GO:0000280 | nuclear division | NA | 3.86e-03 | NA | NA |
| GO:0007264 | small GTPase-mediated signal transductio... | NA | 3.86e-03 | NA | NA |
| GO:0033044 | regulation of chromosome organization | NA | 3.96e-03 | NA | NA |
| GO:0048731 | system development | NA | 3.96e-03 | NA | NA |
| GO:0034654 | nucleobase-containing compound biosynthe... | NA | 3.96e-03 | NA | NA |
| GO:0098813 | nuclear chromosome segregation | NA | 4.08e-03 | NA | NA |
| GO:0034983 | peptidyl-lysine deacetylation | NA | 4.09e-03 | NA | NA |
| GO:0051716 | cellular response to stimulus | NA | 4.09e-03 | NA | NA |
| GO:1901987 | regulation of cell cycle phase transitio... | NA | 4.24e-03 | NA | NA |
| GO:0000022 | mitotic spindle elongation | NA | 4.24e-03 | NA | NA |
| GO:0007399 | nervous system development | NA | 4.39e-03 | NA | NA |
| GO:0031327 | negative regulation of cellular biosynth... | NA | 4.46e-03 | NA | NA |
| GO:0031111 | negative regulation of microtubule polym... | NA | 4.61e-03 | NA | NA |
| GO:0009889 | regulation of biosynthetic process | NA | 4.74e-03 | NA | NA |
| GO:0007099 | centriole replication | NA | 4.74e-03 | NA | NA |
| GO:0007346 | regulation of mitotic cell cycle | NA | 4.89e-03 | NA | NA |
| GO:0033043 | regulation of organelle organization | NA | 5.02e-03 | NA | NA |
| GO:0048699 | generation of neurons | NA | 5.05e-03 | 3.63e-02 | NA |
| GO:0006259 | DNA metabolic process | NA | 5.05e-03 | NA | NA |
| GO:0009888 | tissue development | NA | 5.22e-03 | NA | NA |
| GO:0010558 | negative regulation of macromolecule bio... | NA | 5.24e-03 | NA | NA |
| GO:0048513 | animal organ development | NA | 5.89e-03 | NA | NA |
| GO:0032502 | developmental process | NA | 5.97e-03 | NA | NA |
| GO:0031109 | microtubule polymerization or depolymeri... | NA | 5.99e-03 | NA | NA |
| GO:0007052 | mitotic spindle organization | NA | 6.17e-03 | NA | NA |
| GO:0009890 | negative regulation of biosynthetic proc... | NA | 6.40e-03 | NA | NA |
| GO:0030030 | cell projection organization | NA | 6.83e-03 | 3.35e-03 | NA |
| GO:0006282 | regulation of DNA repair | NA | 7.32e-03 | NA | NA |
| GO:0031324 | negative regulation of cellular metaboli... | NA | 7.32e-03 | NA | NA |
| GO:0051987 | positive regulation of attachment of spi... | NA | 7.43e-03 | NA | NA |
| GO:0006468 | protein phosphorylation | NA | 8.42e-03 | NA | NA |
| GO:0051983 | regulation of chromosome segregation | NA | 9.10e-03 | NA | NA |
| GO:0051256 | mitotic spindle midzone assembly | NA | 9.18e-03 | NA | NA |
| GO:1902275 | regulation of chromatin organization | NA | 9.99e-03 | NA | NA |
| GO:2000779 | regulation of double-strand break repair | NA | 9.99e-03 | NA | NA |
| GO:0048869 | cellular developmental process | NA | 1.07e-02 | NA | NA |
| GO:1902850 | microtubule cytoskeleton organization in... | NA | 1.19e-02 | NA | NA |
| GO:0030154 | cell differentiation | NA | 1.19e-02 | NA | NA |
| GO:0032501 | multicellular organismal process | NA | 1.23e-02 | NA | NA |
| GO:0048468 | cell development | NA | 1.33e-02 | NA | NA |
| GO:0007026 | negative regulation of microtubule depol... | NA | 1.33e-02 | NA | NA |
| GO:0044770 | cell cycle phase transition | NA | 1.35e-02 | NA | NA |
| GO:0045814 | negative regulation of gene expression, ... | NA | 1.36e-02 | NA | NA |
| GO:0002295 | T-helper cell lineage commitment | NA | 1.54e-02 | NA | NA |
| GO:0034244 | negative regulation of transcription elo... | NA | 1.70e-02 | NA | NA |
| GO:0006996 | organelle organization | NA | 1.70e-02 | 1.67e-02 | NA |
| GO:0051298 | centrosome duplication | NA | 2.14e-02 | NA | NA |
| GO:1901990 | regulation of mitotic cell cycle phase t... | NA | 2.18e-02 | NA | NA |
| GO:0021999 | neural plate anterior/posterior regional... | NA | 2.21e-02 | NA | NA |
| GO:0051054 | positive regulation of DNA metabolic pro... | NA | 2.21e-02 | NA | NA |
| GO:0070507 | regulation of microtubule cytoskeleton o... | NA | 2.26e-02 | NA | NA |
| GO:0031331 | positive regulation of cellular cataboli... | NA | 2.26e-02 | NA | NA |
| GO:0035556 | intracellular signal transduction | NA | 2.26e-02 | NA | NA |
| GO:0034728 | nucleosome organization | NA | 2.33e-02 | NA | NA |
| GO:0045721 | negative regulation of gluconeogenesis | NA | 2.42e-02 | NA | NA |
| GO:0120036 | plasma membrane bounded cell projection ... | NA | 2.42e-02 | 2.24e-03 | NA |
| GO:0009653 | anatomical structure morphogenesis | NA | 2.54e-02 | NA | NA |
| GO:0010172 | embryonic body morphogenesis | NA | 2.56e-02 | NA | NA |
| GO:0006302 | double-strand break repair | NA | 2.60e-02 | NA | NA |
| GO:0043087 | regulation of GTPase activity | NA | 2.63e-02 | NA | NA |
| GO:0048812 | neuron projection morphogenesis | NA | 2.69e-02 | NA | NA |
| GO:0021915 | neural tube development | NA | 2.69e-02 | NA | NA |
| GO:1904781 | positive regulation of protein localizat... | NA | 2.69e-02 | NA | NA |
| GO:0030182 | neuron differentiation | NA | 2.69e-02 | NA | NA |
| GO:0007019 | microtubule depolymerization | NA | 2.69e-02 | NA | NA |
| GO:0010557 | positive regulation of macromolecule bio... | NA | 2.69e-02 | NA | NA |
| GO:0031328 | positive regulation of cellular biosynth... | NA | 2.69e-02 | NA | NA |
| GO:0032785 | negative regulation of DNA-templated tra... | NA | 3.00e-02 | NA | 4.71e-02 |
| GO:2000781 | positive regulation of double-strand bre... | NA | 3.00e-02 | NA | NA |
| GO:0031573 | mitotic intra-S DNA damage checkpoint si... | NA | 3.07e-02 | NA | NA |
| GO:0007088 | regulation of mitotic nuclear division | NA | 3.08e-02 | NA | NA |
| GO:0051782 | negative regulation of cell division | NA | 3.23e-02 | NA | NA |
| GO:0031445 | regulation of heterochromatin formation | NA | 3.31e-02 | NA | NA |
| GO:0045786 | negative regulation of cell cycle | NA | 3.39e-02 | NA | NA |
| GO:0000281 | mitotic cytokinesis | NA | 3.43e-02 | NA | NA |
| GO:0120039 | plasma membrane bounded cell projection ... | NA | 3.43e-02 | NA | NA |
| GO:0050896 | response to stimulus | NA | 3.45e-02 | NA | NA |
| GO:0046785 | microtubule polymerization | NA | 3.52e-02 | NA | NA |
| GO:0009891 | positive regulation of biosynthetic proc... | NA | 3.53e-02 | NA | NA |
| GO:0090068 | positive regulation of cell cycle proces... | NA | 3.56e-02 | NA | NA |
| GO:0031048 | regulatory ncRNA-mediated heterochromati... | NA | 3.56e-02 | NA | NA |
| GO:0048858 | cell projection morphogenesis | NA | 3.56e-02 | NA | NA |
| GO:1903939 | regulation of TORC2 signaling | NA | 3.58e-02 | NA | NA |
| GO:0010948 | negative regulation of cell cycle proces... | NA | 3.60e-02 | NA | NA |
| GO:0030263 | apoptotic chromosome condensation | NA | 3.60e-02 | NA | NA |
| GO:2001251 | negative regulation of chromosome organi... | NA | 3.68e-02 | NA | NA |
| GO:0072540 | T-helper 17 cell lineage commitment | NA | 3.71e-02 | NA | NA |
| GO:0010457 | centriole-centriole cohesion | NA | 3.84e-02 | NA | NA |
| GO:0048285 | organelle fission | NA | 3.98e-02 | NA | NA |
| GO:0010720 | positive regulation of cell development | NA | 4.00e-02 | NA | NA |
| GO:0051231 | spindle elongation | NA | 4.00e-02 | NA | NA |
| GO:0044380 | protein localization to cytoskeleton | NA | 4.03e-02 | NA | NA |
| GO:0050772 | positive regulation of axonogenesis | NA | 4.11e-02 | NA | NA |
| GO:0006884 | cell volume homeostasis | NA | 4.15e-02 | NA | NA |
| GO:0030866 | cortical actin cytoskeleton organization | NA | 4.31e-02 | NA | NA |
| GO:0048522 | positive regulation of cellular process | NA | 4.31e-02 | NA | NA |
| GO:0033045 | regulation of sister chromatid segregati... | NA | 4.34e-02 | NA | NA |
| GO:0031110 | regulation of microtubule polymerization... | NA | 4.96e-02 | NA | NA |
| GO:0048518 | positive regulation of biological proces... | NA | 4.96e-02 | NA | NA |
| GO:0036289 | peptidyl-serine autophosphorylation | NA | 5.00e-02 | NA | NA |
| GO:0016192 | vesicle-mediated transport | NA | NA | 1.96e-05 | NA |
| GO:0051641 | cellular localization | NA | NA | 1.28e-03 | NA |
| GO:0051649 | establishment of localization in cell | NA | NA | 1.73e-03 | NA |
| GO:0033036 | macromolecule localization | NA | NA | 1.74e-03 | NA |
| GO:0044088 | regulation of vacuole organization | NA | NA | 1.74e-03 | NA |
| GO:0070727 | cellular macromolecule localization | NA | NA | 2.24e-03 | NA |
| GO:0008104 | protein localization | NA | NA | 2.66e-03 | NA |
| GO:0046907 | intracellular transport | NA | NA | 3.19e-03 | NA |
| GO:0007033 | vacuole organization | NA | NA | 3.35e-03 | NA |
| GO:0015031 | protein transport | NA | NA | 4.42e-03 | NA |
| GO:0016197 | endosomal transport | NA | NA | 5.99e-03 | NA |
| GO:1903944 | negative regulation of hepatocyte apopto... | NA | NA | 6.29e-03 | NA |
| GO:0010743 | regulation of macrophage derived foam ce... | NA | NA | 6.38e-03 | NA |
| GO:0046348 | amino sugar catabolic process | NA | NA | 7.10e-03 | NA |
| GO:0016050 | vesicle organization | NA | NA | 7.10e-03 | NA |
| GO:0045184 | establishment of protein localization | NA | NA | 1.12e-02 | NA |
| GO:0051130 | positive regulation of cellular componen... | NA | NA | 1.12e-02 | NA |
| GO:0006886 | intracellular protein transport | NA | NA | 1.14e-02 | NA |
| GO:0060271 | cilium assembly | NA | NA | 1.14e-02 | NA |
| GO:1903943 | regulation of hepatocyte apoptotic proce... | NA | NA | 1.28e-02 | NA |
| GO:2000785 | regulation of autophagosome assembly | NA | NA | 1.54e-02 | NA |
| GO:0044782 | cilium organization | NA | NA | 1.54e-02 | NA |
| GO:0120031 | plasma membrane bounded cell projection ... | NA | NA | 2.01e-02 | NA |
| GO:0007030 | Golgi organization | NA | NA | 2.01e-02 | NA |
| GO:0051179 | localization | NA | NA | 2.01e-02 | NA |
| GO:0030031 | cell projection assembly | NA | NA | 2.08e-02 | NA |
| GO:0019953 | sexual reproduction | NA | NA | 2.33e-02 | NA |
| GO:0070925 | organelle assembly | NA | NA | 2.36e-02 | NA |
| GO:0048609 | multicellular organismal reproductive pr... | NA | NA | 2.44e-02 | NA |
| GO:0071705 | nitrogen compound transport | NA | NA | 2.44e-02 | NA |
| GO:1905515 | non-motile cilium assembly | NA | NA | 2.49e-02 | NA |
| GO:0007034 | vacuolar transport | NA | NA | 2.49e-02 | NA |
| GO:0044248 | cellular catabolic process | NA | NA | 2.49e-02 | NA |
| GO:0010745 | negative regulation of macrophage derive... | NA | NA | 2.49e-02 | NA |
| GO:0048193 | Golgi vesicle transport | NA | NA | 3.21e-02 | NA |
| GO:0007276 | gamete generation | NA | NA | 3.26e-02 | NA |
| GO:0010256 | endomembrane system organization | NA | NA | 3.31e-02 | NA |
| GO:0007626 | locomotory behavior | NA | NA | 3.38e-02 | NA |
| GO:0072001 | renal system development | NA | NA | 3.70e-02 | NA |
| GO:0007040 | lysosome organization | NA | NA | 3.70e-02 | NA |
| GO:0080171 | lytic vacuole organization | NA | NA | 3.70e-02 | NA |
| GO:0048666 | neuron development | NA | NA | 3.70e-02 | NA |
| GO:0046856 | phosphatidylinositol dephosphorylation | NA | NA | 3.80e-02 | NA |
| GO:0019262 | N-acetylneuraminate catabolic process | NA | NA | 3.90e-02 | NA |
| GO:0002092 | positive regulation of receptor internal... | NA | NA | 3.90e-02 | NA |
| GO:0006897 | endocytosis | NA | NA | 3.93e-02 | NA |
| GO:0051129 | negative regulation of cellular componen... | NA | NA | 4.79e-02 | NA |
| GO:1901072 | glucosamine-containing compound cataboli... | NA | NA | 4.96e-02 | NA |
| GO:0021694 | cerebellar Purkinje cell layer formation | NA | NA | 4.96e-02 | NA |
| GO:0042254 | ribosome biogenesis | NA | NA | NA | 3.59e-05 |
| GO:0016072 | rRNA metabolic process | NA | NA | NA | 4.08e-05 |
| GO:0006364 | rRNA processing | NA | NA | NA | 3.53e-04 |
| GO:0000727 | double-strand break repair via break-ind... | NA | NA | NA | 1.14e-03 |
| GO:0022613 | ribonucleoprotein complex biogenesis | NA | NA | NA | 1.35e-03 |
| GO:0042274 | ribosomal small subunit biogenesis | NA | NA | NA | 1.68e-02 |
| GO:0006560 | proline metabolic process | NA | NA | NA | 2.25e-02 |
| GO:0010155 | regulation of proton transport | NA | NA | NA | 2.69e-02 |
| GO:0006561 | proline biosynthetic process | NA | NA | NA | 2.69e-02 |
| GO:0055129 | L-proline biosynthetic process | NA | NA | NA | 2.69e-02 |
| GO:0006735 | NADH regeneration | NA | NA | NA | 2.69e-02 |
| GO:0061621 | canonical glycolysis | NA | NA | NA | 2.69e-02 |
| GO:0061718 | glucose catabolic process to pyruvate | NA | NA | NA | 2.69e-02 |
| GO:0072527 | pyrimidine-containing compound metabolic... | NA | NA | NA | 3.02e-02 |
| GO:0061620 | glycolytic process through glucose-6-pho... | NA | NA | NA | 3.02e-02 |
| GO:0006271 | DNA strand elongation involved in DNA re... | NA | NA | NA | 3.35e-02 |
| GO:0006399 | tRNA metabolic process | NA | NA | NA | 4.18e-02 |
| GO:0044283 | small molecule biosynthetic process | NA | NA | NA | 4.18e-02 |
| GO:0009141 | nucleoside triphosphate metabolic proces... | NA | NA | NA | 4.18e-02 |
| GO:0009260 | ribonucleotide biosynthetic process | NA | NA | NA | 4.18e-02 |
| GO:0044281 | small molecule metabolic process | NA | NA | NA | 4.60e-02 |
| GO:0042273 | ribosomal large subunit biogenesis | NA | NA | NA | 4.62e-02 |
| GO:0090329 | regulation of DNA-templated DNA replicat... | NA | NA | NA | 4.71e-02 |
| GO:1901293 | nucleoside phosphate biosynthetic proces... | NA | NA | NA | 4.71e-02 |
| GO:0046390 | ribose phosphate biosynthetic process | NA | NA | NA | 4.71e-02 |
| GO:0006220 | pyrimidine nucleotide metabolic process | NA | NA | NA | 4.71e-02 |
| GO:0032075 | positive regulation of nuclease activity | NA | NA | NA | 4.91e-02 |
| GO:0009199 | ribonucleoside triphosphate metabolic pr... | NA | NA | NA | 4.91e-02 |
| GO:0009220 | pyrimidine ribonucleotide biosynthetic p... | NA | NA | NA | 4.92e-02 |
| GO:0006261 | DNA-templated DNA replication | NA | NA | NA | 4.92e-02 |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0006338 | chromatin remodeling | NA | 5.57e-04 | NA |
| GO:0006325 | chromatin organization | NA | 2.82e-03 | NA |
| GO:0032785 | negative regulation of DNA-templated tra... | NA | 7.12e-03 | NA |
| GO:0034244 | negative regulation of transcription elo... | NA | 8.80e-03 | NA |
| GO:0000122 | negative regulation of transcription by ... | NA | 8.99e-03 | NA |
| GO:0045892 | negative regulation of DNA-templated tra... | NA | 2.06e-02 | NA |
| GO:0000727 | double-strand break repair via break-ind... | NA | 2.35e-02 | NA |
| GO:0000022 | mitotic spindle elongation | NA | 2.35e-02 | NA |
| GO:1902679 | negative regulation of RNA biosynthetic ... | NA | 2.35e-02 | NA |
| GO:0045934 | negative regulation of nucleobase-contai... | NA | 3.40e-02 | NA |
| GO:0006261 | DNA-templated DNA replication | NA | 4.03e-02 | NA |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0031347 | regulation of defense response | 7.47e-14 | NA | NA | NA |
| GO:0080134 | regulation of response to stress | 7.47e-14 | NA | NA | NA |
| GO:0010608 | post-transcriptional regulation of gene ... | 8.13e-14 | NA | NA | NA |
| GO:0009894 | regulation of catabolic process | 1.15e-13 | NA | NA | NA |
| GO:0000278 | mitotic cell cycle | 2.42e-13 | NA | NA | NA |
| GO:1903047 | mitotic cell cycle process | 2.42e-13 | NA | NA | NA |
| GO:0007049 | cell cycle | 2.53e-13 | NA | NA | NA |
| GO:0022402 | cell cycle process | 2.53e-13 | NA | NA | NA |
| GO:0031399 | regulation of protein modification proce... | 4.62e-13 | NA | NA | NA |
| GO:0044770 | cell cycle phase transition | 4.62e-13 | NA | NA | NA |
| GO:0051276 | chromosome organization | 5.99e-13 | NA | NA | NA |
| GO:0051052 | regulation of DNA metabolic process | 8.23e-13 | NA | NA | NA |
| GO:0006974 | DNA damage response | 8.77e-13 | NA | NA | NA |
| GO:0009057 | macromolecule catabolic process | 9.28e-13 | NA | NA | NA |
| GO:0006259 | DNA metabolic process | 9.28e-13 | NA | NA | NA |
| GO:0030163 | protein catabolic process | 5.44e-12 | NA | NA | NA |
| GO:0032787 | monocarboxylic acid metabolic process | 9.56e-12 | NA | NA | NA |
| GO:0140546 | defense response to symbiont | 2.02e-08 | NA | NA | NA |
| GO:0045087 | innate immune response | 6.50e-08 | NA | NA | NA |
| GO:0009889 | regulation of biosynthetic process | 1.05e-06 | NA | NA | NA |
| GO:0031326 | regulation of cellular biosynthetic proc... | 1.05e-06 | NA | NA | NA |
| GO:0031323 | regulation of cellular metabolic process | 1.08e-06 | NA | NA | NA |
| GO:0019222 | regulation of metabolic process | 1.46e-06 | NA | NA | NA |
| GO:0090304 | nucleic acid metabolic process | 2.74e-06 | NA | NA | NA |
| GO:0060255 | regulation of macromolecule metabolic pr... | 3.33e-06 | NA | NA | NA |
| GO:0010468 | regulation of gene expression | 8.46e-06 | NA | NA | NA |
| GO:0010556 | regulation of macromolecule biosynthetic... | 8.46e-06 | NA | NA | NA |
| GO:0044249 | cellular biosynthetic process | 9.39e-06 | NA | NA | NA |
| GO:0080090 | regulation of primary metabolic process | 2.18e-05 | NA | NA | NA |
| GO:0016070 | RNA metabolic process | 2.30e-05 | NA | NA | NA |
| GO:0032774 | RNA biosynthetic process | 2.30e-05 | NA | NA | NA |
| GO:0141187 | nucleic acid biosynthetic process | 2.30e-05 | NA | NA | NA |
| GO:0009059 | macromolecule biosynthetic process | 6.10e-05 | NA | NA | NA |
| GO:0010467 | gene expression | 6.10e-05 | NA | NA | NA |
| GO:0043170 | macromolecule metabolic process | 1.26e-04 | NA | NA | NA |
| GO:0019219 | regulation of nucleobase-containing comp... | 2.29e-04 | NA | NA | NA |
| GO:0051252 | regulation of RNA metabolic process | 7.73e-04 | NA | NA | NA |
| GO:0010604 | positive regulation of macromolecule met... | 7.90e-04 | NA | NA | NA |
| GO:0009893 | positive regulation of metabolic process | 8.77e-04 | NA | NA | NA |
| GO:0009891 | positive regulation of biosynthetic proc... | 1.84e-03 | NA | NA | NA |
| GO:0031328 | positive regulation of cellular biosynth... | 1.84e-03 | NA | NA | NA |
| GO:0006351 | DNA-templated transcription | 2.46e-03 | NA | NA | NA |
| GO:0050794 | regulation of cellular process | 2.62e-03 | NA | NA | NA |
| GO:0050789 | regulation of biological process | 3.21e-03 | NA | NA | NA |
| GO:0031325 | positive regulation of cellular metaboli... | 3.98e-03 | NA | NA | NA |
| GO:0031324 | negative regulation of cellular metaboli... | 4.59e-03 | NA | NA | NA |
| GO:0006355 | regulation of DNA-templated transcriptio... | 5.95e-03 | NA | NA | NA |
| GO:2001141 | regulation of RNA biosynthetic process | 5.95e-03 | NA | NA | NA |
| GO:0010557 | positive regulation of macromolecule bio... | 9.75e-03 | NA | NA | NA |
| GO:0043412 | macromolecule modification | 1.21e-02 | NA | NA | NA |
| GO:0048518 | positive regulation of biological proces... | 1.35e-02 | NA | NA | NA |
| GO:0006357 | regulation of transcription by RNA polym... | 1.39e-02 | NA | NA | NA |
| GO:0006366 | transcription by RNA polymerase II | 1.39e-02 | NA | NA | NA |
| GO:0048523 | negative regulation of cellular process | 1.52e-02 | NA | NA | NA |
| GO:0048519 | negative regulation of biological proces... | 1.53e-02 | NA | NA | NA |
| GO:0045184 | establishment of protein localization | 1.86e-02 | NA | NA | NA |
| GO:0065007 | biological regulation | 2.24e-02 | NA | NA | NA |
| GO:0048585 | negative regulation of response to stimu... | 2.24e-02 | NA | NA | NA |
| GO:0036211 | protein modification process | 2.42e-02 | NA | NA | NA |
| GO:0045935 | positive regulation of nucleobase-contai... | 2.46e-02 | NA | NA | NA |
| GO:0009890 | negative regulation of biosynthetic proc... | 2.46e-02 | NA | NA | NA |
| GO:0010558 | negative regulation of macromolecule bio... | 2.46e-02 | NA | NA | NA |
| GO:0031327 | negative regulation of cellular biosynth... | 2.46e-02 | NA | NA | NA |
| GO:0048522 | positive regulation of cellular process | 3.18e-02 | NA | NA | NA |
| GO:0009892 | negative regulation of metabolic process | 3.21e-02 | NA | NA | NA |
| GO:0051246 | regulation of protein metabolic process | 3.25e-02 | NA | NA | NA |
| GO:0009056 | catabolic process | 3.25e-02 | NA | NA | NA |
| GO:0015031 | protein transport | 3.93e-02 | NA | NA | NA |
| GO:0008219 | cell death | 4.03e-02 | NA | NA | NA |
| GO:0012501 | programmed cell death | 4.03e-02 | NA | NA | NA |
| GO:0033036 | macromolecule localization | 4.03e-02 | NA | NA | NA |
| GO:0033554 | cellular response to stress | 4.12e-02 | NA | NA | NA |
| GO:0009968 | negative regulation of signal transducti... | 4.60e-02 | NA | NA | NA |
| GO:0009058 | biosynthetic process | 4.80e-02 | NA | NA | NA |
| GO:0051254 | positive regulation of RNA metabolic pro... | 4.80e-02 | NA | NA | NA |
| GO:0070482 | response to oxygen levels | NA | 1.82e-21 | 2.01e-03 | NA |
| GO:0001666 | response to hypoxia | NA | 1.82e-21 | 7.07e-03 | NA |
| GO:0036293 | response to decreased oxygen levels | NA | 1.82e-21 | 7.07e-03 | NA |
| GO:0006164 | purine nucleotide biosynthetic process | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0006754 | ATP biosynthetic process | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0009142 | nucleoside triphosphate biosynthetic pro... | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0009145 | purine nucleoside triphosphate biosynthe... | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0009152 | purine ribonucleotide biosynthetic proce... | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0009165 | nucleotide biosynthetic process | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0009201 | ribonucleoside triphosphate biosynthetic... | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0009206 | purine ribonucleoside triphosphate biosy... | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0009260 | ribonucleotide biosynthetic process | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0015986 | proton motive force-driven ATP synthesis | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0042776 | proton motive force-driven mitochondrial... | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0046390 | ribose phosphate biosynthetic process | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0072522 | purine-containing compound biosynthetic ... | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0090407 | organophosphate biosynthetic process | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:1901137 | carbohydrate derivative biosynthetic pro... | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:1901293 | nucleoside phosphate biosynthetic proces... | NA | 1.82e-21 | 6.92e-08 | NA |
| GO:0010257 | NADH dehydrogenase complex assembly | NA | 4.45e-21 | 3.84e-14 | NA |
| GO:0032981 | mitochondrial respiratory chain complex ... | NA | 4.45e-21 | 3.84e-14 | NA |
| GO:0006120 | mitochondrial electron transport, NADH t... | NA | 4.45e-21 | 1.60e-14 | NA |
| GO:0009060 | aerobic respiration | NA | 7.72e-08 | 3.44e-08 | NA |
| GO:0015980 | energy derivation by oxidation of organi... | NA | 7.72e-08 | 3.44e-08 | NA |
| GO:0045333 | cellular respiration | NA | 7.72e-08 | 3.44e-08 | NA |
| GO:0006119 | oxidative phosphorylation | NA | 6.00e-07 | 6.92e-08 | NA |
| GO:0022900 | electron transport chain | NA | 4.04e-06 | 3.41e-04 | NA |
| GO:1902600 | proton transmembrane transport | NA | 4.04e-06 | 2.05e-07 | NA |
| GO:0019646 | aerobic electron transport chain | NA | 2.26e-05 | 6.92e-08 | NA |
| GO:0022904 | respiratory electron transport chain | NA | 2.26e-05 | 6.92e-08 | NA |
| GO:0042773 | ATP synthesis coupled electron transport | NA | 2.26e-05 | 6.92e-08 | NA |
| GO:0042775 | mitochondrial ATP synthesis coupled elec... | NA | 2.26e-05 | 6.92e-08 | NA |
| GO:0098660 | inorganic ion transmembrane transport | NA | 3.80e-05 | NA | NA |
| GO:0098662 | inorganic cation transmembrane transport | NA | 3.80e-05 | NA | NA |
| GO:0006091 | generation of precursor metabolites and ... | NA | 1.26e-04 | 2.76e-04 | NA |
| GO:0006811 | monoatomic ion transport | NA | 1.96e-04 | NA | NA |
| GO:0006812 | monoatomic cation transport | NA | 1.96e-04 | NA | NA |
| GO:0034220 | monoatomic ion transmembrane transport | NA | 5.62e-04 | NA | NA |
| GO:0098655 | monoatomic cation transmembrane transpor... | NA | 5.62e-04 | NA | NA |
| GO:0055085 | transmembrane transport | NA | 3.66e-03 | NA | NA |
| GO:0006163 | purine nucleotide metabolic process | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0006753 | nucleoside phosphate metabolic process | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0009117 | nucleotide metabolic process | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0009141 | nucleoside triphosphate metabolic proces... | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0009144 | purine nucleoside triphosphate metabolic... | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0009150 | purine ribonucleotide metabolic process | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0009199 | ribonucleoside triphosphate metabolic pr... | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0009205 | purine ribonucleoside triphosphate metab... | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0009259 | ribonucleotide metabolic process | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0019637 | organophosphate metabolic process | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0019693 | ribose phosphate metabolic process | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0046034 | ATP metabolic process | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0055086 | nucleobase-containing small molecule met... | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0072521 | purine-containing compound metabolic pro... | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:1901135 | carbohydrate derivative metabolic proces... | NA | 7.57e-03 | 1.00e-02 | NA |
| GO:0014070 | response to organic cyclic compound | NA | 1.51e-02 | NA | NA |
| GO:0033108 | mitochondrial respiratory chain complex ... | NA | NA | 3.72e-14 | NA |
| GO:0097250 | mitochondrial respirasome assembly | NA | NA | 3.72e-14 | NA |
| GO:0043933 | protein-containing complex organization | NA | NA | 9.67e-03 | NA |
| GO:0065003 | protein-containing complex assembly | NA | NA | 1.29e-02 | NA |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| NA | NA | NA | NA | NA |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0044391 | ribosomal subunit | 1.32e-41 | NA | NA | 6.64e-05 |
| GO:0022625 | cytosolic large ribosomal subunit | 5.84e-32 | NA | NA | 6.75e-05 |
| GO:0005840 | ribosome | 1.05e-27 | NA | NA | 1.09e-03 |
| GO:0022626 | cytosolic ribosome | 2.36e-26 | NA | NA | 1.87e-02 |
| GO:0015934 | large ribosomal subunit | 6.61e-25 | NA | NA | 6.75e-05 |
| GO:0043230 | extracellular organelle | 3.76e-23 | NA | NA | NA |
| GO:0065010 | extracellular membrane-bounded organelle | 3.76e-23 | NA | NA | NA |
| GO:0070062 | extracellular exosome | 3.76e-23 | NA | NA | NA |
| GO:1903561 | extracellular vesicle | 4.60e-23 | NA | NA | NA |
| GO:0022627 | cytosolic small ribosomal subunit | 1.41e-18 | NA | NA | NA |
| GO:0005615 | extracellular space | 1.41e-18 | NA | NA | NA |
| GO:0005576 | extracellular region | 1.85e-18 | NA | NA | NA |
| GO:0015935 | small ribosomal subunit | 1.35e-17 | NA | NA | NA |
| GO:0005743 | mitochondrial inner membrane | 1.13e-15 | NA | NA | 8.74e-06 |
| GO:0005740 | mitochondrial envelope | 2.94e-15 | NA | NA | 4.30e-04 |
| GO:0019866 | organelle inner membrane | 3.21e-15 | NA | NA | 8.74e-06 |
| GO:0031966 | mitochondrial membrane | 1.57e-14 | NA | NA | 1.79e-03 |
| GO:0031090 | organelle membrane | 3.51e-13 | NA | NA | NA |
| GO:0031982 | vesicle | 3.00e-11 | NA | NA | NA |
| GO:0005739 | mitochondrion | 3.54e-11 | NA | NA | 4.30e-05 |
| GO:0005783 | endoplasmic reticulum | 1.14e-09 | NA | NA | NA |
| GO:0098798 | mitochondrial protein-containing complex | 1.42e-09 | NA | NA | 4.52e-03 |
| GO:0031967 | organelle envelope | 3.21e-09 | NA | NA | 1.63e-02 |
| GO:1990904 | ribonucleoprotein complex | 3.38e-08 | NA | NA | 3.05e-04 |
| GO:0030141 | secretory granule | 6.45e-08 | NA | NA | NA |
| GO:0098796 | membrane protein complex | 1.14e-07 | NA | NA | NA |
| GO:0000313 | organellar ribosome | 1.14e-07 | NA | NA | NA |
| GO:0005761 | mitochondrial ribosome | 1.14e-07 | NA | NA | NA |
| GO:0042175 | nuclear outer membrane-endoplasmic retic... | 2.60e-07 | NA | NA | NA |
| GO:0005789 | endoplasmic reticulum membrane | 2.79e-07 | NA | NA | NA |
| GO:0098827 | endoplasmic reticulum subcompartment | 3.38e-07 | NA | NA | NA |
| GO:0005925 | focal adhesion | 8.59e-07 | NA | NA | 2.57e-02 |
| GO:0030055 | cell-substrate junction | 1.32e-06 | NA | NA | 2.66e-02 |
| GO:0099503 | secretory vesicle | 2.26e-06 | NA | NA | NA |
| GO:0000315 | organellar large ribosomal subunit | 5.37e-06 | NA | NA | NA |
| GO:0005762 | mitochondrial large ribosomal subunit | 5.37e-06 | NA | NA | NA |
| GO:0005759 | mitochondrial matrix | 5.42e-06 | NA | NA | 1.09e-03 |
| GO:0012505 | endomembrane system | 1.05e-05 | NA | NA | NA |
| GO:0098803 | respiratory chain complex | 1.27e-05 | NA | NA | NA |
| GO:0035577 | azurophil granule membrane | 4.07e-05 | NA | NA | NA |
| GO:0016020 | membrane | 1.12e-04 | NA | NA | NA |
| GO:1990351 | transporter complex | 1.30e-04 | NA | NA | NA |
| GO:0030667 | secretory granule membrane | 1.70e-04 | NA | NA | NA |
| GO:0005766 | primary lysosome | 1.77e-04 | NA | NA | NA |
| GO:0042582 | azurophil granule | 1.77e-04 | NA | NA | NA |
| GO:0031984 | organelle subcompartment | 2.76e-04 | NA | NA | NA |
| GO:0000314 | organellar small ribosomal subunit | 4.87e-04 | NA | NA | NA |
| GO:0005763 | mitochondrial small ribosomal subunit | 4.87e-04 | NA | NA | NA |
| GO:0098556 | cytoplasmic side of rough endoplasmic re... | 7.10e-04 | NA | NA | NA |
| GO:1902495 | transmembrane transporter complex | 7.39e-04 | NA | NA | NA |
| GO:0042470 | melanosome | 7.76e-04 | NA | NA | NA |
| GO:0048770 | pigment granule | 7.76e-04 | NA | NA | NA |
| GO:0016469 | proton-transporting two-sector ATPase co... | 9.24e-04 | NA | NA | NA |
| GO:0140534 | endoplasmic reticulum protein-containing... | 9.26e-04 | NA | NA | NA |
| GO:0005758 | mitochondrial intermembrane space | 1.00e-03 | NA | NA | NA |
| GO:0030662 | coated vesicle membrane | 1.17e-03 | NA | NA | NA |
| GO:1905369 | endopeptidase complex | 1.23e-03 | NA | NA | NA |
| GO:0098588 | bounding membrane of organelle | 1.50e-03 | NA | NA | NA |
| GO:0005688 | U6 snRNP | 1.53e-03 | NA | NA | NA |
| GO:0097197 | tetraspanin-enriched microdomain | 1.58e-03 | NA | NA | NA |
| GO:0030135 | coated vesicle | 2.00e-03 | NA | NA | NA |
| GO:0042719 | mitochondrial intermembrane space protei... | 2.06e-03 | NA | NA | NA |
| GO:0043227 | membrane-bounded organelle | 2.46e-03 | NA | NA | NA |
| GO:0005885 | Arp2/3 protein complex | 2.46e-03 | NA | NA | NA |
| GO:0101002 | ficolin-1-rich granule | 2.56e-03 | NA | NA | NA |
| GO:0031983 | vesicle lumen | 2.63e-03 | NA | NA | NA |
| GO:0060205 | cytoplasmic vesicle lumen | 2.63e-03 | NA | NA | NA |
| GO:0030659 | cytoplasmic vesicle membrane | 2.81e-03 | NA | 4.84e-02 | NA |
| GO:0000502 | proteasome complex | 3.57e-03 | NA | NA | NA |
| GO:0098857 | membrane microdomain | 3.65e-03 | NA | NA | NA |
| GO:0030670 | phagocytic vesicle membrane | 3.91e-03 | NA | NA | NA |
| GO:0034774 | secretory granule lumen | 3.93e-03 | NA | NA | NA |
| GO:0012506 | vesicle membrane | 4.04e-03 | NA | NA | NA |
| GO:0045261 | proton-transporting ATP synthase complex... | 4.07e-03 | NA | NA | NA |
| GO:0120115 | Lsm2-8 complex | 4.10e-03 | NA | NA | NA |
| GO:1904813 | ficolin-1-rich granule lumen | 4.15e-03 | NA | NA | NA |
| GO:0005787 | signal peptidase complex | 4.30e-03 | NA | NA | NA |
| GO:1990204 | oxidoreductase complex | 4.30e-03 | NA | NA | NA |
| GO:0070820 | tertiary granule | 4.34e-03 | NA | NA | NA |
| GO:0005683 | U7 snRNP | 4.65e-03 | NA | NA | NA |
| GO:0140596 | TOM complex | 5.40e-03 | NA | NA | NA |
| GO:0045121 | membrane raft | 5.92e-03 | NA | NA | NA |
| GO:0031410 | cytoplasmic vesicle | 6.45e-03 | NA | NA | NA |
| GO:0005834 | heterotrimeric G-protein complex | 6.79e-03 | NA | NA | NA |
| GO:0031970 | organelle envelope lumen | 7.05e-03 | NA | NA | NA |
| GO:0071204 | histone pre-mRNA 3'end processing comple... | 8.39e-03 | NA | NA | NA |
| GO:0030134 | COPII-coated ER to Golgi transport vesic... | 8.48e-03 | NA | NA | NA |
| GO:0097708 | intracellular vesicle | 8.50e-03 | NA | 4.84e-02 | NA |
| GO:0030666 | endocytic vesicle membrane | 9.81e-03 | NA | NA | NA |
| GO:0090533 | cation-transporting ATPase complex | 1.46e-02 | NA | NA | NA |
| GO:0045259 | proton-transporting ATP synthase complex | 1.57e-02 | NA | NA | NA |
| GO:1905368 | peptidase complex | 1.66e-02 | NA | NA | NA |
| GO:0030665 | clathrin-coated vesicle membrane | 1.68e-02 | NA | NA | NA |
| GO:0001405 | PAM complex, Tim23 associated import mot... | 1.70e-02 | NA | NA | NA |
| GO:0043231 | intracellular membrane-bounded organelle | 1.87e-02 | NA | NA | NA |
| GO:0005839 | proteasome core complex | 1.87e-02 | NA | NA | NA |
| GO:0009986 | cell surface | 2.01e-02 | NA | NA | NA |
| GO:0008250 | oligosaccharyltransferase complex | 2.09e-02 | NA | NA | NA |
| GO:0033178 | proton-transporting two-sector ATPase co... | 2.53e-02 | NA | NA | NA |
| GO:1905360 | GTPase complex | 2.54e-02 | NA | NA | NA |
| GO:0030133 | transport vesicle | 2.64e-02 | NA | 2.81e-02 | NA |
| GO:0005744 | TIM23 mitochondrial import inner membran... | 2.65e-02 | NA | NA | 2.57e-02 |
| GO:0005838 | proteasome regulatory particle | 3.10e-02 | NA | NA | NA |
| GO:0005791 | rough endoplasmic reticulum | 3.39e-02 | NA | NA | NA |
| GO:0043505 | CENP-A containing nucleosome | 3.60e-02 | NA | NA | NA |
| GO:0061638 | CENP-A containing chromatin | 3.60e-02 | NA | NA | NA |
| GO:0036126 | sperm flagellum | 3.60e-02 | NA | NA | NA |
| GO:0072546 | EMC complex | 3.63e-02 | NA | NA | NA |
| GO:0005765 | lysosomal membrane | 3.63e-02 | NA | 4.63e-03 | NA |
| GO:0098852 | lytic vacuole membrane | 3.63e-02 | NA | 4.63e-03 | NA |
| GO:0098800 | inner mitochondrial membrane protein com... | 3.63e-02 | NA | NA | 1.02e-02 |
| GO:0097729 | 9+2 motile cilium | 3.69e-02 | NA | NA | NA |
| GO:0034715 | pICln-Sm protein complex | 3.78e-02 | NA | NA | NA |
| GO:0098552 | side of membrane | 3.80e-02 | NA | NA | NA |
| GO:0032991 | protein-containing complex | 4.02e-02 | NA | NA | NA |
| GO:0034709 | methylosome | 4.46e-02 | NA | NA | NA |
| GO:0005774 | vacuolar membrane | 4.46e-02 | NA | 1.76e-03 | NA |
| GO:0030136 | clathrin-coated vesicle | 4.47e-02 | NA | NA | NA |
| GO:0062023 | collagen-containing extracellular matrix | 4.72e-02 | NA | NA | NA |
| GO:0045335 | phagocytic vesicle | 4.96e-02 | NA | NA | NA |
| GO:0070821 | tertiary granule membrane | 4.96e-02 | NA | NA | NA |
| GO:0005694 | chromosome | NA | 2.88e-11 | NA | NA |
| GO:0005856 | cytoskeleton | NA | 7.38e-10 | NA | NA |
| GO:0000785 | chromatin | NA | 9.21e-10 | NA | NA |
| GO:0015630 | microtubule cytoskeleton | NA | 4.77e-09 | NA | NA |
| GO:0043228 | non-membrane-bounded organelle | NA | 3.22e-08 | NA | NA |
| GO:0043232 | intracellular non-membrane-bounded organ... | NA | 3.22e-08 | NA | NA |
| GO:0005815 | microtubule organizing center | NA | 2.82e-07 | 2.03e-02 | NA |
| GO:0005814 | centriole | NA | 3.53e-07 | NA | NA |
| GO:0005654 | nucleoplasm | NA | 1.26e-05 | NA | NA |
| GO:0005813 | centrosome | NA | 3.83e-05 | 1.76e-03 | NA |
| GO:0016604 | nuclear body | NA | 1.23e-04 | 2.96e-03 | NA |
| GO:0031981 | nuclear lumen | NA | 2.28e-04 | NA | NA |
| GO:0016607 | nuclear speck | NA | 5.03e-04 | NA | NA |
| GO:0035097 | histone methyltransferase complex | NA | 1.54e-03 | NA | NA |
| GO:0005634 | nucleus | NA | 2.56e-03 | NA | NA |
| GO:0000922 | spindle pole | NA | 2.60e-03 | NA | NA |
| GO:0099512 | supramolecular fiber | NA | 3.14e-03 | NA | NA |
| GO:0099081 | supramolecular polymer | NA | 3.56e-03 | NA | NA |
| GO:0034451 | centriolar satellite | NA | 4.76e-03 | NA | NA |
| GO:0140513 | nuclear protein-containing complex | NA | 4.76e-03 | NA | NA |
| GO:0034399 | nuclear periphery | NA | 5.98e-03 | NA | NA |
| GO:0005819 | spindle | NA | 7.58e-03 | NA | NA |
| GO:0005874 | microtubule | NA | 7.58e-03 | NA | NA |
| GO:0032437 | cuticular plate | NA | 7.58e-03 | NA | NA |
| GO:0099513 | polymeric cytoskeletal fiber | NA | 8.33e-03 | NA | NA |
| GO:0036064 | ciliary basal body | NA | 8.81e-03 | NA | NA |
| GO:0035976 | transcription factor AP-1 complex | NA | 1.21e-02 | NA | NA |
| GO:0016363 | nuclear matrix | NA | 1.21e-02 | NA | NA |
| GO:0099080 | supramolecular complex | NA | 1.32e-02 | NA | NA |
| GO:0070603 | SWI/SNF superfamily-type complex | NA | 1.65e-02 | NA | NA |
| GO:0044665 | MLL1/2 complex | NA | 1.79e-02 | NA | NA |
| GO:0031931 | TORC1 complex | NA | 1.99e-02 | NA | NA |
| GO:0042995 | cell projection | NA | 2.62e-02 | NA | NA |
| GO:0005871 | kinesin complex | NA | 2.65e-02 | NA | NA |
| GO:0005859 | muscle myosin complex | NA | 2.65e-02 | NA | NA |
| GO:0035371 | microtubule plus-end | NA | 2.65e-02 | NA | NA |
| GO:0014731 | spectrin-associated cytoskeleton | NA | 2.70e-02 | NA | NA |
| GO:0000347 | THO complex | NA | 2.70e-02 | NA | NA |
| GO:0000445 | THO complex part of transcription export... | NA | 2.70e-02 | NA | NA |
| GO:0048786 | presynaptic active zone | NA | 2.70e-02 | NA | NA |
| GO:0071339 | MLL1 complex | NA | 2.70e-02 | NA | NA |
| GO:1990752 | microtubule end | NA | 2.92e-02 | NA | NA |
| GO:0070776 | MOZ/MORF histone acetyltransferase compl... | NA | 3.39e-02 | NA | NA |
| GO:0090543 | Flemming body | NA | 3.39e-02 | NA | NA |
| GO:0120025 | plasma membrane bounded cell projection | NA | 3.39e-02 | NA | NA |
| GO:0070775 | H3 histone acetyltransferase complex | NA | 3.85e-02 | NA | NA |
| GO:0099023 | vesicle tethering complex | NA | 3.85e-02 | NA | NA |
| GO:0030686 | 90S preribosome | NA | 3.85e-02 | NA | NA |
| GO:0005622 | intracellular anatomical structure | NA | 4.72e-02 | 4.84e-02 | NA |
| GO:0005770 | late endosome | NA | NA | 3.22e-05 | NA |
| GO:0005768 | endosome | NA | NA | 1.16e-04 | NA |
| GO:0005773 | vacuole | NA | NA | 1.80e-04 | NA |
| GO:0000323 | lytic vacuole | NA | NA | 4.65e-04 | NA |
| GO:0005764 | lysosome | NA | NA | 4.65e-04 | NA |
| GO:0005769 | early endosome | NA | NA | 5.28e-04 | NA |
| GO:0010008 | endosome membrane | NA | NA | 8.85e-04 | NA |
| GO:0005802 | trans-Golgi network | NA | NA | 1.05e-03 | NA |
| GO:0031902 | late endosome membrane | NA | NA | 1.65e-03 | NA |
| GO:0031901 | early endosome membrane | NA | NA | 2.53e-03 | NA |
| GO:0098791 | Golgi apparatus subcompartment | NA | NA | 1.06e-02 | NA |
| GO:0000776 | kinetochore | NA | NA | 2.87e-02 | NA |
| GO:0098793 | presynapse | NA | NA | 3.70e-02 | NA |
| GO:0008021 | synaptic vesicle | NA | NA | 4.79e-02 | NA |
| GO:0000779 | condensed chromosome, centromeric region | NA | NA | 4.84e-02 | NA |
| GO:0042827 | platelet dense granule | NA | NA | 4.84e-02 | NA |
| GO:0005942 | phosphatidylinositol 3-kinase complex | NA | NA | 4.84e-02 | NA |
| GO:0005829 | cytosol | NA | NA | 4.84e-02 | NA |
| GO:0071162 | CMG complex | NA | NA | NA | 1.79e-03 |
| GO:0030684 | preribosome | NA | NA | NA | 2.08e-03 |
| GO:0031261 | DNA replication preinitiation complex | NA | NA | NA | 3.63e-03 |
| GO:0032040 | small-subunit processome | NA | NA | NA | 1.02e-02 |
| GO:0031390 | Ctf18 RFC-like complex | NA | NA | NA | 1.18e-02 |
| GO:0001725 | stress fiber | NA | NA | NA | 2.51e-02 |
| GO:0097517 | contractile actin filament bundle | NA | NA | NA | 2.51e-02 |
| GO:0043527 | tRNA methyltransferase complex | NA | NA | NA | 3.48e-02 |
| GO:0032432 | actin filament bundle | NA | NA | NA | 4.02e-02 |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0099503 | secretory vesicle | 5.22e-03 | NA | NA |
| GO:0030893 | meiotic cohesin complex | 2.95e-02 | NA | NA |
| GO:0098793 | presynapse | 2.95e-02 | NA | NA |
| GO:0031983 | vesicle lumen | 2.95e-02 | NA | NA |
| GO:0060205 | cytoplasmic vesicle lumen | 2.95e-02 | NA | NA |
| GO:0034774 | secretory granule lumen | 2.97e-02 | NA | NA |
| GO:0005694 | chromosome | NA | 5.60e-03 | NA |
| GO:0000785 | chromatin | NA | 9.75e-03 | NA |
| GO:0043228 | non-membrane-bounded organelle | NA | 9.75e-03 | NA |
| GO:0043232 | intracellular non-membrane-bounded organ... | NA | 9.75e-03 | NA |
| GO:0031094 | platelet dense tubular network | NA | 3.98e-02 | NA |
| GO:0031095 | platelet dense tubular network membrane | NA | 3.98e-02 | NA |
| GO:0140513 | nuclear protein-containing complex | NA | 3.98e-02 | NA |
| GO:0030686 | 90S preribosome | NA | 3.98e-02 | NA |
| GO:0031931 | TORC1 complex | NA | 3.98e-02 | NA |
| GO:0005654 | nucleoplasm | NA | 3.98e-02 | NA |
| GO:0005856 | cytoskeleton | NA | 3.98e-02 | NA |
| GO:1903561 | extracellular vesicle | NA | NA | 3.72e-03 |
| GO:0043230 | extracellular organelle | NA | NA | 3.72e-03 |
| GO:0065010 | extracellular membrane-bounded organelle | NA | NA | 3.72e-03 |
| GO:0044391 | ribosomal subunit | NA | NA | 3.97e-03 |
| GO:0070062 | extracellular exosome | NA | NA | 4.46e-03 |
| GO:0031982 | vesicle | NA | NA | 8.56e-03 |
| GO:0030135 | coated vesicle | NA | NA | 3.55e-02 |
| GO:0030662 | coated vesicle membrane | NA | NA | 4.61e-02 |
| GO:0005802 | trans-Golgi network | NA | NA | 4.83e-02 |
| GO:0071204 | histone pre-mRNA 3'end processing comple... | NA | NA | 4.83e-02 |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0000139 | Golgi membrane | 2.08e-13 | NA | NA | NA |
| GO:0048471 | perinuclear region of cytoplasm | 1.45e-12 | NA | NA | NA |
| GO:0000228 | nuclear chromosome | 1.45e-12 | NA | NA | NA |
| GO:0005634 | nucleus | 3.23e-04 | NA | NA | NA |
| GO:0031981 | nuclear lumen | 1.99e-03 | NA | NA | NA |
| GO:0005654 | nucleoplasm | 4.34e-02 | NA | NA | NA |
| GO:0031974 | membrane-enclosed lumen | 4.34e-02 | NA | NA | NA |
| GO:0043233 | organelle lumen | 4.34e-02 | NA | NA | NA |
| GO:0070013 | intracellular organelle lumen | 4.34e-02 | NA | NA | NA |
| GO:0030964 | NADH dehydrogenase complex | NA | 9.39e-22 | 7.82e-15 | NA |
| GO:0045271 | respiratory chain complex I | NA | 9.39e-22 | 7.82e-15 | NA |
| GO:0110165 | cellular anatomical entity | NA | 3.63e-13 | 1.32e-02 | NA |
| GO:1902495 | transmembrane transporter complex | NA | 6.58e-07 | 2.58e-04 | NA |
| GO:1990351 | transporter complex | NA | 6.58e-07 | 2.58e-04 | NA |
| GO:0098803 | respiratory chain complex | NA | 4.08e-06 | 2.33e-07 | NA |
| GO:1990204 | oxidoreductase complex | NA | 2.09e-05 | 1.19e-07 | NA |
| GO:0098796 | membrane protein complex | NA | 2.09e-05 | 1.80e-03 | NA |
| GO:0005743 | mitochondrial inner membrane | NA | 6.92e-05 | 8.76e-09 | NA |
| GO:0031966 | mitochondrial membrane | NA | 2.50e-04 | 2.54e-08 | NA |
| GO:0019866 | organelle inner membrane | NA | 8.14e-04 | 1.12e-07 | NA |
| GO:0005740 | mitochondrial envelope | NA | 1.45e-03 | 9.24e-07 | NA |
| GO:0005739 | mitochondrion | NA | 2.60e-03 | 2.27e-06 | NA |
| GO:0031090 | organelle membrane | NA | 4.49e-03 | NA | NA |
| GO:0031967 | organelle envelope | NA | 1.14e-02 | 7.56e-07 | NA |
| GO:0016020 | membrane | NA | 1.75e-02 | NA | NA |
| GO:1902494 | catalytic complex | NA | NA | 2.31e-03 | NA |
| GO:0070069 | cytochrome complex | NA | NA | 2.79e-02 | NA |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0098588 | bounding membrane of organelle | 1.29e-02 | NA | NA |
| GO:0000228 | nuclear chromosome | 1.29e-02 | NA | NA |
| GO:0005765 | lysosomal membrane | 1.61e-02 | NA | NA |
| GO:0005774 | vacuolar membrane | 1.61e-02 | NA | NA |
| GO:0098852 | lytic vacuole membrane | 1.61e-02 | NA | NA |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0003735 | structural constituent of ribosome | 6.65e-39 | NA | NA | 1.11e-05 |
| GO:0019843 | rRNA binding | 5.24e-07 | NA | NA | NA |
| GO:0005198 | structural molecule activity | 3.84e-06 | NA | NA | NA |
| GO:0003924 | GTPase activity | 6.98e-05 | NA | NA | NA |
| GO:0009055 | electron transfer activity | 1.17e-04 | NA | NA | NA |
| GO:0005525 | GTP binding | 6.35e-04 | NA | NA | NA |
| GO:0019001 | guanyl nucleotide binding | 6.35e-04 | NA | NA | NA |
| GO:0032561 | guanyl ribonucleotide binding | 6.35e-04 | NA | NA | NA |
| GO:0003925 | G protein activity | 1.09e-03 | NA | NA | NA |
| GO:0097177 | mitochondrial ribosome binding | 1.11e-03 | NA | NA | NA |
| GO:0015038 | glutathione disulfide oxidoreductase act... | 1.11e-03 | NA | NA | NA |
| GO:0016491 | oxidoreductase activity | 1.11e-03 | NA | NA | NA |
| GO:0019003 | GDP binding | 1.68e-03 | NA | NA | NA |
| GO:0016209 | antioxidant activity | 1.86e-03 | NA | NA | NA |
| GO:0008430 | selenium binding | 3.91e-03 | NA | NA | NA |
| GO:0016684 | oxidoreductase activity, acting on perox... | 6.32e-03 | NA | NA | NA |
| GO:0004601 | peroxidase activity | 1.07e-02 | NA | NA | NA |
| GO:0015078 | proton transmembrane transporter activit... | 1.86e-02 | NA | NA | NA |
| GO:0032977 | membrane insertase activity | 2.40e-02 | NA | NA | NA |
| GO:0097371 | MDM2/MDM4 family protein binding | 2.42e-02 | NA | NA | NA |
| GO:1903136 | cuprous ion binding | 2.49e-02 | NA | NA | NA |
| GO:0004930 | G protein-coupled receptor activity | 2.96e-02 | NA | NA | NA |
| GO:0061650 | ubiquitin-like protein conjugating enzym... | 3.08e-02 | NA | NA | NA |
| GO:0019763 | immunoglobulin receptor activity | 3.08e-02 | NA | NA | NA |
| GO:0044183 | protein folding chaperone | 3.30e-02 | NA | NA | NA |
| GO:0015165 | pyrimidine nucleotide-sugar transmembran... | 3.30e-02 | NA | NA | NA |
| GO:0051920 | peroxiredoxin activity | 3.30e-02 | NA | NA | NA |
| GO:0031386 | protein tag activity | 3.30e-02 | NA | NA | NA |
| GO:0141047 | molecular tag activity | 3.30e-02 | NA | NA | NA |
| GO:0019864 | IgG binding | 4.27e-02 | NA | NA | NA |
| GO:0015288 | porin activity | 4.35e-02 | NA | NA | NA |
| GO:0005524 | ATP binding | NA | 1.22e-19 | NA | NA |
| GO:0032559 | adenyl ribonucleotide binding | NA | 1.87e-19 | NA | NA |
| GO:0030554 | adenyl nucleotide binding | NA | 4.11e-17 | NA | NA |
| GO:0030695 | GTPase regulator activity | NA | 2.63e-16 | NA | NA |
| GO:0060589 | nucleoside-triphosphatase regulator acti... | NA | 2.63e-16 | NA | NA |
| GO:0005096 | GTPase activator activity | NA | 5.02e-13 | NA | NA |
| GO:0140993 | histone modifying activity | NA | 8.55e-12 | NA | NA |
| GO:0004672 | protein kinase activity | NA | 2.21e-11 | NA | NA |
| GO:0016773 | phosphotransferase activity, alcohol gro... | NA | 6.19e-11 | NA | NA |
| GO:0042393 | histone binding | NA | 6.28e-11 | NA | NA |
| GO:0003682 | chromatin binding | NA | 1.15e-10 | NA | NA |
| GO:0016301 | kinase activity | NA | 1.47e-10 | NA | NA |
| GO:0106310 | protein serine kinase activity | NA | 5.81e-10 | NA | NA |
| GO:0004674 | protein serine/threonine kinase activity | NA | 8.07e-10 | NA | NA |
| GO:0043167 | ion binding | NA | 3.06e-09 | NA | NA |
| GO:0035639 | purine ribonucleoside triphosphate bindi... | NA | 3.88e-09 | NA | NA |
| GO:0032553 | ribonucleotide binding | NA | 5.87e-09 | NA | NA |
| GO:0032555 | purine ribonucleotide binding | NA | 6.68e-09 | NA | NA |
| GO:0043168 | anion binding | NA | 9.32e-09 | NA | NA |
| GO:0016887 | ATP hydrolysis activity | NA | 9.47e-09 | NA | NA |
| GO:0016772 | transferase activity, transferring phosp... | NA | 2.07e-08 | NA | NA |
| GO:0005085 | guanyl-nucleotide exchange factor activi... | NA | 8.40e-08 | NA | NA |
| GO:0017076 | purine nucleotide binding | NA | 1.05e-07 | NA | NA |
| GO:0140657 | ATP-dependent activity | NA | 2.04e-07 | NA | NA |
| GO:0003677 | DNA binding | NA | 2.41e-07 | NA | NA |
| GO:0036094 | small molecule binding | NA | 6.65e-07 | NA | NA |
| GO:1901363 | heterocyclic compound binding | NA | 1.16e-06 | NA | NA |
| GO:1901265 | nucleoside phosphate binding | NA | 1.85e-06 | NA | NA |
| GO:0140030 | modification-dependent protein binding | NA | 1.85e-06 | NA | NA |
| GO:0000166 | nucleotide binding | NA | 2.21e-06 | NA | NA |
| GO:0004386 | helicase activity | NA | 5.21e-06 | NA | NA |
| GO:0035173 | histone kinase activity | NA | 1.18e-05 | NA | NA |
| GO:0097367 | carbohydrate derivative binding | NA | 1.23e-05 | NA | NA |
| GO:0140457 | protein demethylase activity | NA | 1.40e-05 | 2.90e-02 | NA |
| GO:0044024 | histone H2AS1 kinase activity | NA | 1.63e-05 | NA | NA |
| GO:0140995 | histone H2A kinase activity | NA | 1.63e-05 | NA | NA |
| GO:0140096 | catalytic activity, acting on a protein | NA | 1.77e-05 | NA | NA |
| GO:0008017 | microtubule binding | NA | 1.92e-05 | NA | NA |
| GO:0031267 | small GTPase binding | NA | 1.92e-05 | 1.18e-02 | NA |
| GO:0032452 | histone demethylase activity | NA | 2.34e-05 | 4.26e-02 | NA |
| GO:0035091 | phosphatidylinositol binding | NA | 7.44e-05 | NA | NA |
| GO:0046872 | metal ion binding | NA | 7.59e-05 | 1.79e-02 | NA |
| GO:0003712 | transcription coregulator activity | NA | 9.64e-05 | NA | NA |
| GO:0141052 | histone H3 demethylase activity | NA | 1.12e-04 | 1.46e-02 | NA |
| GO:0051020 | GTPase binding | NA | 1.18e-04 | 1.79e-02 | NA |
| GO:0015631 | tubulin binding | NA | 1.47e-04 | NA | NA |
| GO:0043169 | cation binding | NA | 2.07e-04 | 1.79e-02 | NA |
| GO:0035064 | methylated histone binding | NA | 3.08e-04 | NA | NA |
| GO:0140110 | transcription regulator activity | NA | 3.35e-04 | NA | NA |
| GO:0008047 | enzyme activator activity | NA | 5.56e-04 | NA | NA |
| GO:0008381 | mechanosensitive monoatomic ion channel ... | NA | 6.40e-04 | NA | NA |
| GO:0032451 | demethylase activity | NA | 6.40e-04 | NA | NA |
| GO:0140034 | methylation-dependent protein binding | NA | 6.40e-04 | NA | NA |
| GO:0003916 | DNA topoisomerase activity | NA | 6.78e-04 | NA | NA |
| GO:0140947 | histone H3K9me2 methyltransferase activi... | NA | 8.69e-04 | NA | NA |
| GO:0030674 | protein-macromolecule adaptor activity | NA | 8.72e-04 | NA | NA |
| GO:0097159 | organic cyclic compound binding | NA | 1.01e-03 | NA | NA |
| GO:0016706 | 2-oxoglutarate-dependent dioxygenase act... | NA | 1.04e-03 | NA | NA |
| GO:0043565 | sequence-specific DNA binding | NA | 1.10e-03 | NA | NA |
| GO:0005516 | calmodulin binding | NA | 1.35e-03 | NA | NA |
| GO:0140999 | histone H3K4 trimethyltransferase activi... | NA | 1.42e-03 | NA | NA |
| GO:0071889 | 14-3-3 protein binding | NA | 1.42e-03 | NA | NA |
| GO:0140359 | ABC-type transporter activity | NA | 1.72e-03 | NA | NA |
| GO:0003774 | cytoskeletal motor activity | NA | 1.74e-03 | NA | NA |
| GO:0008092 | cytoskeletal protein binding | NA | 1.74e-03 | NA | NA |
| GO:0140658 | ATP-dependent chromatin remodeler activi... | NA | 1.86e-03 | NA | NA |
| GO:0140033 | acetylation-dependent protein binding | NA | 2.17e-03 | NA | NA |
| GO:0140097 | catalytic activity, acting on DNA | NA | 2.51e-03 | NA | NA |
| GO:0016740 | transferase activity | NA | 2.56e-03 | NA | NA |
| GO:0005078 | MAP-kinase scaffold activity | NA | 2.85e-03 | NA | NA |
| GO:0060090 | molecular adaptor activity | NA | 3.10e-03 | NA | NA |
| GO:0004713 | protein tyrosine kinase activity | NA | 3.10e-03 | NA | NA |
| GO:0008443 | phosphofructokinase activity | NA | 3.17e-03 | NA | NA |
| GO:0140938 | histone H3 methyltransferase activity | NA | 3.33e-03 | NA | NA |
| GO:0003713 | transcription coactivator activity | NA | 3.36e-03 | NA | NA |
| GO:0140640 | catalytic activity, acting on a nucleic ... | NA | 3.36e-03 | NA | NA |
| GO:0070577 | lysine-acetylated histone binding | NA | 3.94e-03 | NA | NA |
| GO:0003777 | microtubule motor activity | NA | 4.20e-03 | NA | NA |
| GO:0010484 | histone H3 acetyltransferase activity | NA | 4.77e-03 | NA | NA |
| GO:0005543 | phospholipid binding | NA | 5.13e-03 | NA | NA |
| GO:0008094 | ATP-dependent activity, acting on DNA | NA | 5.16e-03 | NA | NA |
| GO:0008289 | lipid binding | NA | 6.52e-03 | NA | NA |
| GO:0008186 | ATP-dependent activity, acting on RNA | NA | 6.89e-03 | NA | NA |
| GO:0030234 | enzyme regulator activity | NA | 7.12e-03 | NA | NA |
| GO:0046976 | histone H3K27 methyltransferase activity | NA | 8.56e-03 | NA | NA |
| GO:0141039 | phosphatidylinositol 3-kinase inhibitor ... | NA | 9.05e-03 | NA | NA |
| GO:0008349 | MAP kinase kinase kinase kinase activity | NA | 9.89e-03 | NA | NA |
| GO:0034040 | ATPase-coupled lipid transmembrane trans... | NA | 1.09e-02 | NA | NA |
| GO:0003690 | double-stranded DNA binding | NA | 1.09e-02 | NA | NA |
| GO:1904680 | peptide transmembrane transporter activi... | NA | 1.20e-02 | NA | NA |
| GO:0051864 | histone H3K36 demethylase activity | NA | 1.27e-02 | NA | NA |
| GO:0008134 | transcription factor binding | NA | 1.33e-02 | NA | NA |
| GO:0004016 | adenylate cyclase activity | NA | 1.33e-02 | NA | NA |
| GO:0003724 | RNA helicase activity | NA | 1.36e-02 | NA | NA |
| GO:0016741 | transferase activity, transferring one-c... | NA | 1.37e-02 | NA | NA |
| GO:0015278 | intracellularly gated calcium channel ac... | NA | 1.37e-02 | NA | NA |
| GO:1990837 | sequence-specific double-stranded DNA bi... | NA | 1.48e-02 | NA | NA |
| GO:0042054 | histone methyltransferase activity | NA | 1.54e-02 | NA | NA |
| GO:0042162 | telomeric DNA binding | NA | 1.56e-02 | NA | NA |
| GO:0046030 | inositol trisphosphate phosphatase activ... | NA | 1.59e-02 | NA | NA |
| GO:0140939 | histone H4 methyltransferase activity | NA | 1.59e-02 | NA | NA |
| GO:0004709 | MAP kinase kinase kinase activity | NA | 1.64e-02 | NA | NA |
| GO:0005272 | sodium channel activity | NA | 1.69e-02 | NA | NA |
| GO:0022836 | gated channel activity | NA | 1.69e-02 | NA | NA |
| GO:0034647 | histone H3K4me/H3K4me2/H3K4me3 demethyla... | NA | 1.71e-02 | NA | NA |
| GO:0052659 | inositol-1,3,4,5-tetrakisphosphate 5-pho... | NA | 1.72e-02 | NA | NA |
| GO:0051213 | dioxygenase activity | NA | 1.82e-02 | NA | NA |
| GO:0008559 | ABC-type xenobiotic transporter activity | NA | 1.88e-02 | NA | NA |
| GO:0000976 | transcription cis-regulatory region bind... | NA | 2.08e-02 | NA | NA |
| GO:0004812 | aminoacyl-tRNA ligase activity | NA | 2.09e-02 | NA | NA |
| GO:0016875 | ligase activity, forming carbon-oxygen b... | NA | 2.09e-02 | NA | NA |
| GO:0001067 | transcription regulatory region nucleic ... | NA | 2.13e-02 | NA | NA |
| GO:0008168 | methyltransferase activity | NA | 2.48e-02 | NA | NA |
| GO:0003714 | transcription corepressor activity | NA | 2.71e-02 | NA | NA |
| GO:0043225 | ATPase-coupled inorganic anion transmemb... | NA | 2.76e-02 | NA | NA |
| GO:0099604 | ligand-gated calcium channel activity | NA | 3.06e-02 | NA | NA |
| GO:0008170 | N-methyltransferase activity | NA | 3.39e-02 | NA | NA |
| GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate... | NA | 3.73e-02 | NA | NA |
| GO:0050681 | nuclear androgen receptor binding | NA | 3.75e-02 | NA | NA |
| GO:0001227 | DNA-binding transcription repressor acti... | NA | 3.75e-02 | NA | NA |
| GO:0015081 | sodium ion transmembrane transporter act... | NA | 3.81e-02 | NA | NA |
| GO:0043995 | histone H4K5 acetyltransferase activity | NA | 3.90e-02 | NA | NA |
| GO:0043996 | histone H4K8 acetyltransferase activity | NA | 3.90e-02 | NA | NA |
| GO:0042887 | amide transmembrane transporter activity | NA | 4.02e-02 | NA | NA |
| GO:0022834 | ligand-gated channel activity | NA | 4.03e-02 | NA | NA |
| GO:0016849 | phosphorus-oxygen lyase activity | NA | 4.14e-02 | NA | NA |
| GO:1990841 | promoter-specific chromatin binding | NA | 4.29e-02 | NA | NA |
| GO:0016278 | lysine N-methyltransferase activity | NA | 4.29e-02 | NA | NA |
| GO:0016279 | protein-lysine N-methyltransferase activ... | NA | 4.29e-02 | NA | NA |
| GO:0008574 | plus-end-directed microtubule motor acti... | NA | 4.32e-02 | NA | NA |
| GO:1901981 | phosphatidylinositol phosphate binding | NA | 4.32e-02 | NA | NA |
| GO:0015431 | ABC-type glutathione S-conjugate transpo... | NA | 4.32e-02 | NA | NA |
| GO:0015923 | mannosidase activity | NA | 4.32e-02 | NA | NA |
| GO:0004559 | alpha-mannosidase activity | NA | 4.32e-02 | NA | NA |
| GO:0008276 | protein methyltransferase activity | NA | 4.32e-02 | NA | NA |
| GO:0005217 | intracellularly ligand-gated monoatomic ... | NA | 4.32e-02 | NA | NA |
| GO:0001217 | DNA-binding transcription repressor acti... | NA | 4.38e-02 | NA | NA |
| GO:0140297 | DNA-binding transcription factor binding | NA | 4.41e-02 | NA | NA |
| GO:0019901 | protein kinase binding | NA | 4.43e-02 | NA | NA |
| GO:0140566 | histone reader activity | NA | 4.43e-02 | NA | NA |
| GO:0003950 | NAD+-protein poly-ADP-ribosyltransferase... | NA | 4.78e-02 | NA | NA |
| GO:0015276 | ligand-gated monoatomic ion channel acti... | NA | 4.82e-02 | NA | NA |
| GO:0090482 | vitamin transmembrane transporter activi... | NA | 4.85e-02 | NA | NA |
| GO:0046914 | transition metal ion binding | NA | NA | 1.03e-02 | NA |
| GO:0000149 | SNARE binding | NA | NA | 1.03e-02 | NA |
| GO:0008270 | zinc ion binding | NA | NA | 1.22e-02 | NA |
| GO:0043394 | proteoglycan binding | NA | NA | 1.46e-02 | NA |
| GO:0019783 | ubiquitin-like protein peptidase activit... | NA | NA | 1.79e-02 | NA |
| GO:0032454 | histone H3K9 demethylase activity | NA | NA | 2.90e-02 | NA |
| GO:0004843 | cysteine-type deubiquitinase activity | NA | NA | 3.91e-02 | NA |
| GO:0101005 | deubiquitinase activity | NA | NA | 4.00e-02 | NA |
| GO:0005488 | binding | NA | NA | 4.34e-02 | NA |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0070728 | L-leucine binding | 4.31e-02 | NA | NA |
| GO:0005524 | ATP binding | NA | 9.02e-08 | NA |
| GO:0032559 | adenyl ribonucleotide binding | NA | 9.02e-08 | NA |
| GO:0030554 | adenyl nucleotide binding | NA | 1.45e-07 | NA |
| GO:0035639 | purine ribonucleoside triphosphate bindi... | NA | 1.58e-04 | NA |
| GO:0140993 | histone modifying activity | NA | 1.58e-04 | NA |
| GO:0032553 | ribonucleotide binding | NA | 1.64e-04 | NA |
| GO:0032555 | purine ribonucleotide binding | NA | 1.70e-04 | NA |
| GO:1901363 | heterocyclic compound binding | NA | 2.56e-04 | NA |
| GO:0017076 | purine nucleotide binding | NA | 2.56e-04 | NA |
| GO:0016773 | phosphotransferase activity, alcohol gro... | NA | 2.65e-04 | NA |
| GO:1901265 | nucleoside phosphate binding | NA | 3.74e-04 | NA |
| GO:0016301 | kinase activity | NA | 3.74e-04 | NA |
| GO:0000166 | nucleotide binding | NA | 3.82e-04 | NA |
| GO:0106310 | protein serine kinase activity | NA | 4.62e-04 | NA |
| GO:0043168 | anion binding | NA | 4.62e-04 | NA |
| GO:0004674 | protein serine/threonine kinase activity | NA | 5.32e-04 | NA |
| GO:0003682 | chromatin binding | NA | 6.57e-04 | NA |
| GO:0004672 | protein kinase activity | NA | 6.57e-04 | NA |
| GO:0030695 | GTPase regulator activity | NA | 2.45e-03 | NA |
| GO:0060589 | nucleoside-triphosphatase regulator acti... | NA | 2.45e-03 | NA |
| GO:0016772 | transferase activity, transferring phosp... | NA | 2.70e-03 | NA |
| GO:0035242 | protein-arginine omega-N asymmetric meth... | NA | 4.95e-03 | NA |
| GO:0097367 | carbohydrate derivative binding | NA | 5.33e-03 | NA |
| GO:0016741 | transferase activity, transferring one-c... | NA | 5.82e-03 | NA |
| GO:0008168 | methyltransferase activity | NA | 7.95e-03 | NA |
| GO:0042393 | histone binding | NA | 1.13e-02 | NA |
| GO:0008381 | mechanosensitive monoatomic ion channel ... | NA | 1.20e-02 | NA |
| GO:0071889 | 14-3-3 protein binding | NA | 1.92e-02 | NA |
| GO:0003714 | transcription corepressor activity | NA | 2.19e-02 | NA |
| GO:0097159 | organic cyclic compound binding | NA | 2.25e-02 | NA |
| GO:0005096 | GTPase activator activity | NA | 2.25e-02 | NA |
| GO:0001217 | DNA-binding transcription repressor acti... | NA | 2.25e-02 | NA |
| GO:0003712 | transcription coregulator activity | NA | 2.25e-02 | NA |
| GO:0016887 | ATP hydrolysis activity | NA | 2.30e-02 | NA |
| GO:0140416 | transcription regulator inhibitor activi... | NA | 2.34e-02 | NA |
| GO:0035173 | histone kinase activity | NA | 2.44e-02 | NA |
| GO:0001227 | DNA-binding transcription repressor acti... | NA | 2.52e-02 | NA |
| GO:0008276 | protein methyltransferase activity | NA | 3.28e-02 | NA |
| GO:0042054 | histone methyltransferase activity | NA | 3.82e-02 | NA |
| GO:0140030 | modification-dependent protein binding | NA | 4.56e-02 | NA |
| GO:0017020 | myosin phosphatase regulator activity | NA | 4.77e-02 | NA |
| GO:0008757 | S-adenosylmethionine-dependent methyltra... | NA | 4.94e-02 | NA |
| GO:0003735 | structural constituent of ribosome | NA | NA | 7.54e-03 |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0005488 | binding | 2.00e-17 | NA | NA | NA |
| GO:0008270 | zinc ion binding | 1.21e-13 | NA | NA | NA |
| GO:0030674 | protein-macromolecule adaptor activity | 6.64e-13 | NA | NA | NA |
| GO:0000977 | RNA polymerase II transcription regulato... | 7.40e-10 | NA | NA | NA |
| GO:0003723 | RNA binding | 7.59e-03 | NA | NA | NA |
| GO:0003677 | DNA binding | 2.82e-02 | NA | NA | NA |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | NA | 2.34e-21 | 1.92e-15 | NA |
| GO:0016651 | oxidoreductase activity, acting on NAD(P... | NA | 2.34e-21 | 1.92e-15 | NA |
| GO:0016655 | oxidoreductase activity, acting on NAD(P... | NA | 2.34e-21 | 1.92e-15 | NA |
| GO:0015078 | proton transmembrane transporter activit... | NA | 7.88e-07 | 6.22e-08 | NA |
| GO:0008324 | monoatomic cation transmembrane transpor... | NA | 6.30e-06 | 2.79e-02 | NA |
| GO:0015075 | monoatomic ion transmembrane transporter... | NA | 6.30e-06 | 2.79e-02 | NA |
| GO:0015318 | inorganic molecular entity transmembrane... | NA | 6.30e-06 | 2.79e-02 | NA |
| GO:0022857 | transmembrane transporter activity | NA | 6.30e-06 | 2.79e-02 | NA |
| GO:0022890 | inorganic cation transmembrane transport... | NA | 6.30e-06 | 2.79e-02 | NA |
| GO:0009055 | electron transfer activity | NA | 1.26e-05 | 6.22e-08 | NA |
| GO:0015399 | primary active transmembrane transporter... | NA | 1.26e-05 | 6.22e-08 | NA |
| GO:0015453 | oxidoreduction-driven active transmembra... | NA | 1.26e-05 | 6.22e-08 | NA |
| GO:0005215 | transporter activity | NA | 1.18e-04 | 3.84e-02 | NA |
| GO:0022804 | active transmembrane transporter activit... | NA | 2.87e-04 | 2.79e-02 | NA |
| GO:0022853 | active monoatomic ion transmembrane tran... | NA | 2.87e-04 | 2.79e-02 | NA |
| GO:0016491 | oxidoreductase activity | NA | 9.38e-03 | NA | NA |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0030674 | protein-macromolecule adaptor activity | 2.13e-02 | NA | NA |
| GO:0060090 | molecular adaptor activity | 2.13e-02 | NA | NA |
| final_main_params | |
|---|---|
| model_organism | Human |
| annot_table | NULL |
| input_gene_id | ENSEMBL |
| custom | NULL |
| enrich_dbs | c("Reactome", "KEGG", "BP", "CC", "MF") |
| kegg_data_file | /Users/marmtnez/Desktop/Master_Bioinfo/TFM/installed_software/ExpHunterSuite/inst/scripts/../../inst/kegg_data_files/hsa_KEGG.rds |
| enrich_methods | ORA |
| annotation_source | orgdb |
| pthreshold | 0.1 |
| qthreshold | 0.2 |
| cores | 1 |
| task_size | 10 |
| output_files | /Users/marmtnez/Desktop/Master_Bioinfo/TFM/Results/functional/ctrl_vs_opg_fc1_fe |
| fc_colname | mean_logFCs |
| universe | NULL |
| clean_parentals | FALSE |
| simplify | FALSE |
| top_categories | 50 |
| sim_thr | NULL |
| summary_common_name | ancestor |
| clusters_flag | TRUE |